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. 2025 Feb 27;16:1512740. doi: 10.3389/fphar.2025.1512740

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Copyright © 2025 Ou, Wu, Ning, Huang, Wang, Yang, Zhou, Hou, Li, Chen and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oridonin derivatives inhibited the LPS-induced release of NO from RAW264.7 cells. (A), CCK-8 assay with RAW264.7 cells treated with various concentrations of LPS. (B), NO release assay with RAW264.7 cells treated with various concentrations of LPS. (C), NO release assay with RAW264.7 cells treated with oridonin and its derivatives. The cells were stimulated with 1 μg/mL LPS for 1 h, cocultured with the oridonin derivatives for 24 h, and subjected to a NO release assay. All the results are expressed as the average value ± SD of three independent experiments. # indicates that the difference between the LPS and control groups is significant; and * indicates that the difference between the oridonin derivative and LPS groups is significant. Student’s t-test was used to calculate the significance, #### and ****, p < 0.0001; ### and ***, p < 0.001; ## and **, p < 0.01; # and *, p < 0.05.