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. 2025 Feb 27;16:1512740. doi: 10.3389/fphar.2025.1512740

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Copyright © 2025 Ou, Wu, Ning, Huang, Wang, Yang, Zhou, Hou, Li, Chen and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Compounds 4b and 4c inhibited the expression of inflammatory proteins. (A), WB analysis of p-NF-κB, NF-κB, p-IκBα, IκBα, COX-2, NLRP3, IL-6 and iNOS. RAW264.7 cells were pretreated with LPS for 1 h, coincubated with 4b and 4c for 24 h, and then subjected to WB analysis. (B–M), Quantification of the results of WB analysis of inflammatory proteins. All the results are expressed as the average value ± SD of three independent experiments. # indicates that the difference between the LPS and control groups is significant; and * indicates that the difference between the oridonin derivative and LPS groups is significant. Student’s t-test was used to calculate the significance, #### and ****, p < 0.0001; ### and ***, p < 0.001; ## and **, p < 0.01; # and *, p < 0.05.