Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2025 Feb 27;16:1512740. doi: 10.3389/fphar.2025.1512740

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2025 Ou, Wu, Ning, Huang, Wang, Yang, Zhou, Hou, Li, Chen and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

RNA-sequencing revealed that 4c regulated inflammatory signaling pathways. (A), Volcano plot showing the differentially expressed genes. RAW264.7 cells were pretreated with LPS for 1 h, cocultured with or without 0.312 μM 4c for 24 h, and then subjected to RNA-seq analysis. (B), Cluster heatmap displaying the differentially expressed genes in RAW264.7 cells in the control group, LPS group, and LPS and 4c coculture group. (C, D), Gene Ontology (GO) analysis of the differentially expressed genes. (E, F), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of the differentially expressed genes.