Table 2.
Annual volumetric changes in the CLAD group.
| 3 year period (n = 8) | 1 year (n = 28) | 2 year (n = 17) | 3 year (n = 8) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | p value | Std | Mean | p value | Std | Mean | p value | Std | Mean | p value | Std | |
| BrainSeg | -1.132 | 0.149 | 1.978 | -0.699 | 0.012 | 1.378 | -0.428 | 0.096 | 0.998 | -0.073 | 0.901 | 1.611 |
| TotalGray | −2.192 | 0.095 | 3.216 | −0.100 | 0.779 | 1.863 | −0.879 | 0.031 | 1.648 | 0.527 | 0.486 | 2.026 |
| Cortex | −2.492 | 0.120 | 3.976 | 0.069 | 0.728 | 2.262 | −0.935 | 0.057 | 2.175 | 0.090 | 0.895 | 1.866 |
| SubCortGray | −0.863 | 0.294 | 2.154 | −0.408 | 0.206 | 1.667 | −0.360 | 0.046 | 0.687 | 0.270 | 0.751 | 2.310 |
| Cerebellar cortex | −1.477 | 0.418 | 4.857 | −0.592 | 0.171 | 2.226 | −0.846 | 0.078 | 1.850 | 2.318 | 0.170 | 4.289 |
| WM total | 0.153 | 0.547 | 6.354 | −1.646 | 0.005 | 4.035 | 0.035 | 0.970 | 3.829 | −0.710 | 0.516 | 2.934 |
| Cerebral WM | 0.371 | 0.547 | 6.639 | −1.708 | 0.003 | 4.195 | 0.056 | 0.953 | 3.890 | −0.753 | 0.480 | 2.854 |
| Cerebellar WM | −3.836 | 0.050 | 4.593 | −0.322 | 0.840 | 8.353 | −0.292 | 0.885 | 8.197 | 0.453 | 0.888 | 8.740 |
| WM-hypo | −9.371 | 0.163 | 17.019 | −4.197 | 0.268 | 19.655 | 9.703 | 0.027 | 22.650 | 8.251 | 0.742 | 28.164 |
| Hippocampus | 2.366 | 0.005 | 1.637 | 0.945 | 0.077 | 2.719 | −0.525 | 0.361 | 2.303 | 0.930 | 0.341 | 2.573 |
| Thalamus | 0.277 | 0.896 | 5.770 | 0.116 | 0.863 | 3.538 | −0.256 | 0.552 | 1.734 | −0.109 | 0.933 | 3.550 |
| Amygdala | 0.022 | 0.990 | 4.682 | −0.105 | 0.868 | 3.322 | −0.540 | 0.498 | 3.212 | 2.312 | 0.178 | 4.370 |
| VentralDC | −2.980 | 0.017 | 2.716 | −1.280 | 0.037 | 3.085 | −0.777 | 0.167 | 2.215 | 0.227 | 0.805 | 2.500 |
| Accumbens-area | −6.264 | 0.109 | 9.638 | −2.625 | 0.161 | 9.638 | −0.008 | 0.995 | 5.622 | −3.086 | 0.314 | 8.048 |
| Pallidium | 0.392 | 0.932 | 12.521 | 0.075 | 0.955 | 7.008 | −1.774 | 0.118 | 4.428 | 0.586 | 0.814 | 6.778 |
| Putamen | −0.739 | 0.763 | 6.655 | −0.194 | 0.778 | 3.611 | 0.730 | 0.240 | 2.464 | 0.297 | 0.818 | 3.520 |
| Caudate | −2.897 | 0.231 | 6.249 | −1.536 | 0.157 | 5.577 | −0.596 | 0.332 | 2.454 | 0.099 | 0.952 | 4.482 |
| CC | 8.216 | 0.742 | 28.027 | −0.932 | 0.652 | 10.834 | 0.599 | 0.747 | 3.769 | 4.350 | 0.353 | 12.367 |
| Lateral ventricle | 12.643 | 0.081 | 17.576 | 4.177 | 0.056 | 10.057 | 1.943 | 0.124 | 4.939 | 3.587 | 0.360 | 10.368 |
| VentricleChoroidVol | 11.106 | 0.101 | 16.662 | 3.799 | 0.099 | 9.893 | 1.912 | 0.040 | 4.918 | 3.098 | 0.412 | 10.051 |
| CSF | −2.492 | 0.534 | 10.772 | −0.559 | 0.451 | 8.656 | 1.446 | 0.351 | 6.206 | −2.194 | 0.063 | 2.815 |
Statistically significant changes are marked in green.