Table 3.
Annual volumetric changes in the ALEM group.
| 3 year period (n = 7) | 1 year (n = 13) | 2 year (n = 14) | 3 year (n = 10) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | p value | Std | Mean | p value | Std | Mean | p value | Std | Mean | p value | Std | |
| BrainSeg | −1.164 | 0.049 | 1.253 | −0.376 | 0.093 | 0.742 | −0.111 | 0.651 | 0.900 | −0.675 | 0.227 | 1.647 |
| TotalGray | 0.259 | 0.833 | 3.114 | −0.042 | 0.916 | 1.406 | −0.272 | 0.566 | 1.727 | 0.809 | 0.144 | 1.599 |
| Cortex | 1.279 | 0.452 | 4.209 | 0.405 | 0.430 | 1.791 | −0.581 | 0.074 | 2.162 | 1.376 | 0.035 | 1.756 |
| SubCortGray | −2.462 | 0.105 | 3.415 | −1.585 | 0.003 | 1.576 | −0.064 | 0.510 | 1.724 | −0.090 | 0.880 | 1.819 |
| Cerebellar cortex | −2.167 | 0.217 | 4.154 | −1.095 | 0.033 | 1.902 | 0.739 | 0.271 | 2.404 | −0.723 | 0.262 | 1.908 |
| WM total | −2.988 | 0.208 | 5.597 | −0.745 | 0.083 | 1.420 | 0.190 | 0.124 | 2.448 | −2.581 | 0.098 | 4.421 |
| Cerebral WM | −3.069 | 0.215 | 5.852 | −0.706 | 0.113 | 1.488 | 0.311 | 0.124 | 2.433 | −2.881 | 0.069 | 4.417 |
| Cerebellar WM | −1.074 | 0.589 | 4.989 | −1.040 | 0.382 | 4.129 | −2.466 | 0.163 | 6.240 | 3.374 | 0.135 | 6.494 |
| WM-hypo | −21.566 | 0.016 | 22.796 | 3.848 | 0.455 | 20.104 | −0.246 | 0.950 | 14.376 | −22.972 | 0.012 | 23.322 |
| Hippocampus | −3.572 | 0.101 | 4.887 | −3.525 | 0.004 | 3.627 | −0.372 | 0.634 | 2.862 | 0.439 | 0.695 | 4.567 |
| Thalamus | 1.192 | 0.702 | 7.869 | 0.231 | 0.735 | 3.597 | 1.001 | 0.875 | 5.567 | 0.813 | 0.468 | 3.395 |
| Amygdala | −7.926 | 0.008 | 5.345 | −3.041 | 0.049 | 4.994 | 0.092 | 0.331 | 5.911 | −1.193 | 0.245 | 3.034 |
| VentralDC | −3.303 | 0.010 | 2.360 | −1.447 | 0.091 | 2.842 | −0.054 | 0.221 | 3.867 | −1.557 | 0.097 | 2.654 |
| Accumbens-area | 5.376 | 0.578 | 14.602 | 3.084 | 0.521 | 16.817 | −1.197 | 0.537 | 7.063 | 2.157 | 0.539 | 10.693 |
| Pallidium | −4.770 | 0.404 | 14.058 | −4.078 | 0.027 | 10.468 | 2.818 | 0.331 | 10.945 | −3.485 | 0.284 | 9.666 |
| Putamen | 0.172 | 0.961 | 8.829 | 3.276 | 0.168 | 8.656 | −2.935 | 0.074 | 7.745 | 3.193 | 0.232 | 9.270 |
| Caudate | −0.937 | 0.375 | 11.167 | −5.298 | 0.013 | 9.567 | 0.224 | 0.510 | 8.234 | 1.669 | 0.294 | 4.732 |
| CC | 5.517 | 0.642 | 29.867 | 5.689 | 0.340 | 26.378 | 4.072 | 0.730 | 22.834 | −1.240 | 0.592 | 7.061 |
| Lateral ventricle | 3.588 | 0.715 | 24.781 | 3.442 | 0.103 | 7.025 | −0.015 | 0.245 | 12.254 | 1.322 | 0.492 | 12.160 |
| VentricleChoroidVol | 3.682 | 0.713 | 25.263 | 4.243 | 0.032 | 6.318 | 0.354 | 0.177 | 12.164 | 1.243 | 0.432 | 12.734 |
| CSF | −11.271 | 0.109 | 15.828 | −1.078 | 0.713 | 10.335 | 1.733 | 0.087 | 17.304 | −3.072 | 0.478 | 13.124 |
Statistically significant changes are marked in green.