Table 3.
Analysis of the determinants of the paired mean differences between the healthy and affected brain hemispheric sides
| Outcome: IFOF mean length (mm) | Outcome: IFOF volume (cm3) | |||||
|---|---|---|---|---|---|---|
| Characteristic | Adj. β | 95% CI | p-value | Adj. β | 95% CI | p-value |
| Group | ||||||
| Affected | — | — | — | — | ||
| Healthy | 5.7 | 4.2, 7.3 | < 0.001 | 10 | 8.4, 12 | < 0.001 |
| Sex | ||||||
| Female | — | — | — | — | ||
| Male | 0.62 | −5.4, 6.6 | 0.838 | 3.1 | 0.50, 5.8 | 0.020 |
| Age (y) | 0.01 | −0.28, 0.30 | 0.939 | −0.08 | −0.20, 0.05 | 0.233 |
| Diagnosis | ||||||
| GBM | — | — | — | — | ||
| LGG | −12 | −23, −0.64 | 0.039 | 8.9 | 3.8, 14 | < 0.001 |
| Meningioma | 37 | 26, 48 | < 0.001 | −7.7 | −12, −3.0 | 0.002 |
| Metastasis | 6.4 | −3.2, 16 | 0.187 | −0.73 | −5.0, 3.5 | 0.732 |
| Side | ||||||
| Left | — | — | — | — | ||
| Right | 0.08 | −6.5, 6.7 | 0.980 | −0.33 | −3.2, 2.6 | 0.820 |
| Volume – EN cm3 | −0.40 | −0.59, −0.21 | < 0.001 | 0.15 | 0.07, 0.24 | < 0.001 |
|
Volume—FLAIR hyperintensity beyond EN cm3 |
0.08 | −0.02, 0.18 | 0.131 | −0.10 | −0.15, −0.06 | < 0.001 |
IFOF, inferior fronto-occipital fasciculus, Adj. β adjusted beta value, CI confidence interval, GBM glioblastoma multiforme, LGG low-grade gliomas, EN enhancing nodule