. 2025 Feb 28;10(9):9703–9717. doi: 10.1021/acsomega.4c11076

Table 2. Evaluation of the Inhibitory Activities of the Selected Thiazolo-quinazolines 4 and 5, in Comparison with Ciprofloxacin, Against S. aureus DNA Gyrase^a.

	IC₅₀(μM) (mean ± SEM)
Compd. No.	S. aureusDNA gyrase supercoiling
4	11.72 ± 0.47
5	7.13 ± 0.28
Ciprofloxacin	19.3 ± 0.73

IC50: The compound concentration required to inhibit 50% of the enzyme activity, represented by the standard error of the mean (SEM). Each value corresponds to the average of three readings.

Table 2. Evaluation of the Inhibitory Activities of the Selected Thiazolo-quinazolines 4 and 5, in Comparison with Ciprofloxacin, Against S. aureus DNA Gyrasea.

Table 2. Evaluation of the Inhibitory Activities of the Selected Thiazolo-quinazolines 4 and 5, in Comparison with Ciprofloxacin, Against S. aureus DNA Gyrase^a.