Table 1.
Demographics and clinical data of the AE patients and HCs.
| AE (n = 176) | HC (n = 200) | p value | |
|---|---|---|---|
| Sex, No (%) | 0.492a | ||
| Male | 95 (54.0%) | 115 (57.5%) | |
| Female | 81 (46.0%) | 85 (42.5%) | |
| Age (year, Mean ± SD) | 42.02 ± 18.83 | 40.02 ± 9.94 | 0.207b |
| WBC, 109/L | 8.13 (6.19–10.70) | 6.17 (5.19–7.11) | <0.001c |
| Neutrophils, 109/L (M, IQR) | 5.38 (3.95–7.86) | 3.50 (2.78–4.32) | <0.001c |
| Lymphocytes, 109/L (M, IQR) | 1.65 (1.27–2.08) | 2.07 (1.71–2.49) | <0.001c |
| Monocytes, 109/L (M, IQR) | 0.50 (0.35–0.68) | 0.36 (0.27–0.44) | <0.001c |
| Platelets, 109/L (M, IQR) | 231.00 (196.00–278.00) | 253.50 (225.25–302.50) | 0.001c |
| SII (M, IQR) | 774.34 (477.16–1264.37) | 444.82 (337.58–584.25) | <0.001c |
| NLR (M, IQR) | 3.14 (2.14–4.79) | 1.75 (1.37–2.23) | <0.001c |
| MLR (M, IQR) | 0.30 (0.21–0.42) | 0.17 (0.14–0.21) | <0.001c |
| PLR (M, IQR) | 142.86 (114.79–194.92) | 128.62 (102.80–151.95) | <0.001c |
| CASE (M, IQR) | 7 (4–13) | ||
| mRS (M, IQR) | 2 (1–3) | ||
| Antibody (%) | |||
| NMDAR | 89 (50.57%) | ||
| LGI1 | 47 (26.70%) | ||
| GABA | 10 (5.68%) | ||
| CASPR2 | 7 (3.98%) | ||
| AMPAR | 2 (1.14%) | ||
| GAD65 | 8 (4.55%) | ||
| DPPX | 1 (0.57%) | ||
| mGluR1 | 1 (0.57%) | ||
| mGluR5 | 1 (0.57%) | ||
| lgLON5 | 2 (1.14%) | ||
| GlyR1 | 1 (0.57%) | ||
| Amphiphy | 2 (1.14%) | ||
| CV2 | 1 (0.57%) | ||
| Yo | 1 (0.57%) | ||
| GAD65, Hu | 1 (0.57%) | ||
| AMPAR, AMPH, CV2 | 1 (0.57%) | ||
| NMDA, GAD65 | 1 (0.57%) |
HC, Healthy control; AE, Autoimmune encephalitis; M, Median; IQR, Interquartile range; WBC, White blood cell; NLR, Neutrophil-to-lymphocyte ratio; MLR, Monocyte-to-lymphocyte ratio; PLR, Platelet-to-lymphocyte ratio; SII, Systemic immune-inflammation index; CASE, The clinical assessment scale for autoimmune encephalitis; mRS, Modified rankin scale; NMDAR, Anti-N-methyl-D-aspartate receptor; LGI-1, Leucine-rich glioma inactivated 1; GABA, G-aminobutyric acid type; CASPR2, Contactin associated protein 2; AMPAR, Amino-3-hydroxy-5-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; GAD65, Glutamic acid decarboxylase-65; DPPX, Dipeptidyl-peptiddase-like protein-6; mGluR1, Metabotropic Glutamate Receptor 1; mGluR5, Metabotropic Glutamate Receptor 5; GlyR1, Glycine receptor-1.
Pearson’s chi-square test.
The independent samples T test.
Mann-Whitney U test.