Table 1.
Interactions between OPN isoforms and integrins (α4 and α9): binding energies (ΔG) and interface areas.
| Integrin | OPN-a | OPN-b | OPN-c | OPN-4 | OPN-5 |
|---|---|---|---|---|---|
| △G (kcal/mol) | |||||
| α4 | |||||
| FL-OPN | −11.5 | −9.3 | −1.5 | −9.4 | −18.6 |
| CL-OPN | −20.7 | −26.9 | −18.4 | −11.7 | −7 |
| α9 | |||||
| FL-OPN | −23.7 | −1.8 | −1.2 | −1.8 | −8.5 |
| CL-OPN | −18.0 | −20.9 | −11.6 | −5.2 | −5.5 |
| Interface area (A2) | |||||
| α4 | |||||
| FL-OPN | 3413.2 | 2701.6 | 3087.3 | 2541.8 | 2696.0 |
| CL-OPN | 2795.2 | 3360.9 | 3019.1 | 2215.3 | 2319.1 |
| α9 | |||||
| FL-OPN | 2527.9 | 2124.8 | 2196.5 | 2384.1 | 2300.0 |
| CL-OPN | 2996.4 | 3182.2 | 1912.5 | 2072.2 | 2241.1 |
ΔG, binding energy; CL-OPN, thrombin-cleaved OPN; FL-OPN, full-length OPN.
This table presents the binding energies and interface areas for five OPN isoforms, detailing interactions with integrins both in their full-length form and after thrombin cleavage. A smaller binding energy indicates tighter or more facile bond formation between the OPN isoforms and the integrins.