Table 3.

The mean interaction energies of the drug Ribavirin and Ligs 1–3 and to the viral targets (i.e., SARS-CoV-2 RdRp and HCV NS5B) in a dynamic state.

Compounds	Elec (kj/mol)	VdW (kj/mol)	Total	H-bond
SARS-CoV-2 RdRp
Ribavirin	− 45.02	− 58.04	− 103.06	2.5
Lig-1	− 48.87	− 95.03	− 143.90	1.7
Lig-2	− 30.75	− 64.21	− 94.96	2.1
Lig-3	− 44.01	− 85.63	− 129.64	2.5
HCV NS5B
Ribavirin	− 68.96	− 118.05	− 187.01	3.0
Lig-1	− 15.83	− 82.17	− 98.0	1.5
Lig-2	4.57	− 164.51	− 159.94	2.7
Lig-3	− 24.62	− 141.86	− 166.48	2.9