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. 2025 Mar 13;25:88. doi: 10.1186/s12935-025-03716-y

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — The diagnostic and prognostic value of SERPINI1 in HCC. (A) SERPINI1 expression in various tumors in GEPIA dataset. The red name represents upregulation in the cancer, the green name represents downregulation in the cancer, the black name represents differences without statistically significance. (B) GEPIA dataset showed that the expression of SERPINI1 in HCC. The tumor number = 369, the normal number = 160. (C) The levels of SERPINI1 in serum of patients with HCC (number = 153) and healthy controls (HC) (number = 138) were detected by ELISA. (D) ROC of SERPINI1, AFP, and SERPINI1 + AFP were plotted to distinguish HCC from HC. (E) Overall survival analysis of SERPINI1 high (number = 181) and low (number = 181) expression in HCC in GEPIA dataset. *p-value < 0.05