Table 3.
Antimycobacterial activity of dual action DADHTs.
| Compound | Minimum Inhibitory Concentration (MIC90, μM) | Half-Maximal Inhibitory Concentration (IC50, μM) |
|||
|---|---|---|---|---|---|
| M. tuberculosis H37Rv | M. abscessus L948 | ||||
| MABA: GAST Media | MABA: 7H12 Media |
MABA | Biofilm: Formationa | Biofilm: Preformedb | |
| CYC | >100 | 74.8 | > 200 | > 200 | > 80 |
| 1b | >100 | 48.3 | ntc | nt | nt |
| 1c | 9.2 | 10 | nt | nt | nt |
| 1d | 3.1 | 5.8 | nt | nt | nt |
| 1e | 2.9 | 3 | > 200 | > 200 | > 80 |
| 1f | 6.2 | 4.7 | nt | nt | nt |
| 1g | 10 | 7.7 | nt | nt | nt |
| 2b | >100 | 71.9 | nt | nt | nt |
| 2c | >100 | >100 | nt | nt | nt |
| 2d | >100 | >100 | nt | nt | nt |
| 2e | 5 | 4.6 | nt | nt | nt |
| 2f | 5 | 5.6 | > 200 | > 200 | > 80 |
| 2h | 2.5 | 2.9 | nt | nt | nt |
| 2i | 3.7 | 6.2 | nt | nt | nt |
| 2j | 5.4 | 6.2 | nt | nt | nt |
| 2k | 5.4 | 7.5 | nt | nt | nt |
| 2l | 8.1 | 8.6 | nt | nt | nt |
| 3a | >100 | >100 | nt | nt | nt |
| 3b | 69 | 48.6 | nt | nt | nt |
| 3c | 5.7 | 5.5 | > 200 | > 200 | > 80 |
| 3d | 1.5 | 1.4 | 54.5 | 34.4 | > 80 |
| 3e | 1.3 | 0.7 | 85.2 | 167.3 | > 80 |
| 3f | 28 | 23.3 | nt | nt | nt |
| 3g | 60.4 | 45.4 | nt | nt | nt |
| 3h | 10.2 | 9.7 | nt | nt | nt |
| 4 | 50.8 | 71.3 | nt | nt | nt |
| 5 | nt | nt | 61.6 | 93.1 | > 80 |
| Rifampicin | <0.016 | 0.05 | nt | nt | nt |
| Isoniazid | 0.12 | 0.24 | nt | nt | nt |
| Moxifloxacin | 0.042 | 0.43 | nt | nt | nt |
| Streptomycin | 0.27 | 0.21 | nt | nt | nt |
| Pretomanid | 0.51 | 0.38 | nt | nt | nt |
| Clarithromycin | nt | nt | 15.4 | 11.7 | > 80 |
a
Test compounds were added before biofilms had formed.
b
Test compounds were added after biofilms had formed.
c
nt = not tested.