Table 4. Number of Significant Metabolites From MWAS of POP Mixtures and SBP Percent Changes with Two Cut off Points in the Teen-LABS Study, 2007–2012.
| modea | lipophilic
POP mixturesb |
SBP
percent changes at five years |
||
|---|---|---|---|---|
| raw p-value at 0.01 | PCA-adjusted p-valuec | raw p-value at 0.01 | PCA-adjusted p-valued | |
| C18 ESI– | 74 (2.04%) | 3 (0.08%) | 69 (1.9%) | 1 (0.03%) |
| C18 ESI+ | 41 (0.85%) | 5 (0.1%) | 144 (2.98%) | 5 (0.1%) |
| HILIC ESI– | 84 (1.1%) | 3 (0.04%) | 147 (1.93%) | 1 (0.01%) |
| HILIC ESI+ | 63 (1.19%) | 3 (0.06%) | 131 (2.47%) | 0 (0%) |
Note: models were adjusted for race/ethnicity (non-hispanic white, others), age at baseline (continuous), patient’s sex (male, female), parents’ annual income (<$25,000, $25,000 to $74,999, ≥75,000, unknown), and BMI at baseline (continuous).
The overall effect of the lipophilic POP mixtures was estimated using quantile g-computation.
PCA-adjusted p-values for multiple comparisons indicates the p-value cutoff point at 0.00078.
PCA-adjusted p-values for multiple comparisons indicates the p-value cutoff point at 0.0008. Abbreviations: MWAS, metabolome-wide analysis study; POP, persistent organic pollutant; SBP, systolic blood pressure; ESI, electrospray ion; HILIC, hydrophilic interaction liquid chromatography; PCA, principal component analysis.