Table 5. Identified Metabolites Associated with Lipophilic POP Mixtures in the Teen-LABS Cohort, 2007-2012a.
| overall effectb | partial
effectsc |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| group | metabolites | m/z | RT | column | ψ (95% CI) | p-value | p,p′-DDE | p,p′-DDT | HCB | PCB118 | PCB153 | PBDE47 |
| lipid | palmitoleate | 253.2173 | 335.12 | C18- | –0.682 (−1.134, −0.229) | 0.005 | –0.238 | 0.013 | –0.241 | 0.150 | –0.309 | –0.056 |
| lipid | [C18.4]-stearidonic acid | 275.2017 | 304.52 | C18- | –0.873 (−1.336, −0.409) | 0.001 | –0.163 | –0.075 | –0.185 | 0.019 | –0.274 | –0.194 |
| lipid | [C18.2]-11-octadecen-9-ynoic acid | 277.2173 | 323.27 | C18- | –0.713 (−1.177, −0.249) | 0.004 | –0.355 | 0.208 | –0.325 | –0.038 | –0.197 | –0.007 |
| lipid | [C20.4]-arachidonic acid | 303.2329 | 340.71 | C18- | –0.793 (−1.277, −0.308) | 0.002 | –0.208 | –0.108 | –0.233 | 0.077 | –0.146 | –0.174 |
| amino acid | histidine | 154.0623 | 18.53 | C18- | –0.689 (−1.139, −0.239) | 0.004 | –0.464 | 0.309 | –0.307 | –0.195 | 0.081 | –0.113 |
| amino acid | acetoacetate | 101.0242 | 173.66 | HILIC- | –0.779 (−1.26, −0.298) | 0.003 | –0.319 | –0.029 | –0.229 | –0.048 | 0.011 | –0.164 |
| amino acid | 3-hydroxyanthranilate | 152.0351 | 126.77 | HILIC- | –0.663 (−1.146, −0.18) | 0.010 | –0.073 | –0.123 | –0.234 | 0.005 | –0.162 | –0.076 |
| amino acid | asparagine | 133.0608 | 294.41 | HILIC+ | –0.671 (−1.109, −0.233) | 0.004 | –0.252 | –0.148 | –0.191 | 0.272 | –0.281 | –0.071 |
| amino acid | indole-3-acetate | 176.0706 | 74.06 | HILIC+ | –0.729 (−1.234, −0.223) | 0.007 | –0.150 | –0.192 | –0.210 | 0.156 | –0.204 | –0.130 |
| nucleotide derivatives | hypoxanthine | 137.0458 | 148.33 | HILIC+ | –0.699 (−1.163, −0.235) | 0.005 | –0.034 | –0.124 | –0.186 | –0.010 | –0.094 | –0.252 |
| nucleotide derivatives | inosine | 269.0882 | 183.31 | HILIC+ | –0.700 (−1.192, −0.208) | 0.007 | –0.162 | –0.270 | –0.216 | 0.004 | –0.022 | –0.033 |
| others | N, N-dimethylarginine | 203.1503 | 367.35 | HILIC+ | –0.614 (−1.054, −0.175) | 0.008 | –0.217 | –0.093 | –0.109 | 0.022 | –0.237 | 0.021 |
Note: Models were adjusted for race/ethnicity (non-Hispanic white, others), age at baseline (continuous), patient’s sex (male, female), parents’ annual income (<$25,000, $25,000 to $74,999, ≥75,000, unknown), and BMI at the baseline (continuous).
Overall effect of the lipophilic POP mixture on adipose tissue metabolome was estimated by quantile g-computation. Estimates are interpreted as the overall mixture effect on the log2 intensity of a maternal metabolite for a simultaneous quartile increase in each POPs.
Partial effects were the estimates of each POP relative to the overall effect of POP mixtures either in the positive direction or the negative direction. Abbreviation: m/z, mass-to-charge ratio; RT, retention time; POP, persistent organic pollutant; p,p′-DDE, dichlorodiphenyldichloroethylene; p,p′-DDT, dichlorodiphenyltrichloroethane; HCB, hexachlorobenzene; PCB, polychlorinated biphenyls; PBDE, polybrominated diphenyl ethers; and HILIC, hydrophilic interaction liquid chromatography.