Table 6. Identified Metabolites Associated with SBP Percent Changes at Five Years in the Teen-LABS Cohort, 2007-2012.
| groupa | metabolites | m/z | RT | column | β (95% CI) | p-value |
|---|---|---|---|---|---|---|
| amino acid | hippuric acid | 178.0509 | 23.40 | C18- | –3.88% (−7.24%, −0.524%) | 0.029 |
| amino acid | N-acetylglutamate | 188.0563 | 303.47 | HILIC- | 4.07% (1.13%, 7.01%) | 0.010 |
| amino acid | indole-3-acetate | 176.0706 | 74.06 | HILIC+ | –3.49% (−6.51%, −0.48%) | 0.029 |
| others | choline | 139.0765 | 43.83 | C18- | –3.49% (−6.62%, −0.37%) | 0.034 |
a
Note: models were adjusted race/ethnicity (non-Hispanic white, others), age at baseline (continuous), patient’s sex (male, female), parents’ annual income (<$25,000, $25,000 to $74,999, ≥75,000, unknown), and BMI at the baseline (continuous). Abbreviation: SBP, systolic blood pressure; m/z, mass-to-charge ratio; RT, retention time; HILIC, hydrophilic interaction liquid chromatography.