TABLE 1.
Demographic characteristics of study participants. For further details regarding the recruitment and characteristics of each cohort, see the Supplementary Materials.
| Variable | Overall | DeKAF | FRCBS | GEN03 | KiT-GENIE | QUB | TL | UKIRTC |
|---|---|---|---|---|---|---|---|---|
| Number of transplants | 6,060 | 684 | 888 | 472 | 1,463 | 68 | 608 | 1877 |
| Donor age, median (range) | 50 (18–90) | 44 (18–70) | 58 (18–77) | 45 (18–71) | 56 (18–90) | 44 (18–66) | 46 (18–72) | 47 (18–81) |
| Female donor, n (%) | 2,839 (47) | 405 (59) | 417 (47) | 271 (57) | 616 (42) | 32 (47) | 292 (48) | 806 (43) |
| Donor type | ||||||||
| Living, n (%) | 1,470 (24) | 684 (100) | 0 (0) | 472 (100) | 265 (18) | 0 (0) | 49 (8) | 0 (0) |
| Died of stroke, n (%) | 2,826 (47) | 0 (0) | 585 (66) | 0 (0) | 699 (48) | 42 (62) | 319 (52) | 1,181 (63) |
| Died of other causes, (n %) | 1764 (29) | 0 (0) | 303 (34) | 0 (0) | 499 (34) | 26 (38) | 240 (39) | 696 (37) |
| Recipient age, median (range) | 51 (0–84) | 51 (0–83) | 57 (18–79) | 51 (1–81) | 55 (18–84) | 44 (10–72) | 50 (16–74) | 47 (18–79) |
| Female recipient, n (%) | 2,148 (35) | 231 (34) | 275 (31) | 177 (38) | 497 (34) | 30 (44) | 246 (40) | 692 (37) |
| First transplant, n (%) | 5,337 (88) | 603 (88) | 888 (100) | 418 (89) | 1,140 (78) | 68 (100) | 555 (91) | 1,665 (89) |
| HLA mismatch, median (range) | 3 (0–6) | 3 (0–6) | 3 (0–6) | 3 (0–6) | 4 (0–6) | NA | NA | 2 (0–6) |
| Unknown | 924 (15) | 1 (0.1) | 0 (0) | 13 (3) | 0 (100) | 68 (100) | 608 (100) | 234 (12) |
| Year of transplant, median | 2007 | 2008 | 2014 | 2014 | 2011 | 2002 | 2000 | 2001 |
| Follow up, median (range) | 5 (0–25) | 2 (0–5) | 3 (0–10) | 2 (0–3) | 6 (0–21) | 7 (0–24) | 7 (0–17) | 8 (0–25) |
| Graft status, n (%) | ||||||||
| Censored | 5,098 (84) | 671 (98) | 831 (94) | 470 (100) | 1,138 (78) | 46 (68) | 509 (84) | 1,433 (76) |
| Rejected | 962 (16) | 13 (2) | 57 (6) | 2 (0.4) | 325 (22) | 22 (32) | 99 (16) | 444 (24) |
| eGFR at 1-year, median (range) | 52 (0–185) | 60 (0–178) | 54 (0–135) | 62 (16–185) | 50 (0–129) | 0 (0–0) | 45 (0–124) | 49 (0–124) |
| Unknown, n (%) | 726 (12) | 0 (0) | 247 (28) | 0 (0) | 59 (4) | 53 (78) | 24 (4) | 343 (18) |
| eGFR at 5-year, median (range) | 44 (0–124) | 0 (0–0) | 38 (0–106) | 0 (0–0) | 45 (0–122) | 0 (0–0) | 47 (0–124) | 44 (0–121) |
| Unknown, n (%) | 3037 (50) | 671 (98) | 747 (84) | 470 (99.5) | 491 (34) | 49 (72) | 139 (23) | 470 (25) |
DeKAF, deterioration of kidney allograft function; FRCBS, finnish red cross blood service; GEN03, genomics of kidney transplantation; KiT-GENIE, kidney transplantation - genomic investigation of essential clinical concerns; QUB, Queen’s University Belfast; TL, TransplantLines; UKIRTC, united kingdom and ireland renal transplant consortium; eGFR, estimated glomerular filtration rate.