TABLE 2.
Univariable linear models for recipient eGFR at 1- and 5-year post-transplant, and Cox model for death-censored graft failure.
| eGFR at 1-year | eGFR at 5-year | Graft failure | ||||||
|---|---|---|---|---|---|---|---|---|
| Estimate (SE) | P value | R2 | Estimate (SE) | P value | R2 | HR (95% CI) | P value | |
| Clinical factors | ||||||||
| Donor age | −0.63 (0.02) | <2e-16 | 0.16 | −0.64 (0.03) | <2e-16 | 0.12 | 1.02 (1.02–1.03) | <2e-16 |
| Male donor sex | 3.4 (0.62) | 6.1e-8 | 0.005 | 3.3 (0.98) | 0.001 | 0.004 | 0.98 (0.86–1.1) | 0.72 |
| Male recipient sex | 1.2 (0.65) | 0.06 | 0.001 | 2.5 (1.01) | 0.01 | 0.002 | 1.1 (0.93–1.2) | 0.34 |
| Recipient age | −0.46 (0.02) | <2e-16 | 0.08 | −0.24 (0.04) | 8.2e-12 | 0.02 | 1.00 (0.99–1.01) | 0.29 |
| HLA mismatch | −0.16 (0.20) | 0.43 | 0 | −0.77 (0.33) | 0.02 | 0.001 | 1.1 (1.02–1.11) | 0.006 |
| First transplant | −0.2 (0.94) | 0.83 | 0 | 3.0 (1.38) | 0.03 | 0.002 | 0.66 (0.56–0.78) | 7.9e-7 |
| Year of transplant | 0.45 (0.047) | <2e-16 | 0.02 | −0.15 (0.08) | 0.06 | 0.001 | 0.98 (0.98–0.99) | 0.003 |
| Donor type | 0.1 | 0.03 | ||||||
| Living | - | - | - | - | - | - | ||
| Stroke cause of death | −17 (0.72) | <2e-16 | −13 (1.95) | 1.7e-10 | 3.5 (2.5–4.7) | 1.6e-14 | ||
| Other cause of death | −8.6 (0.79) | <2e-16 | −4.2 (2.01) | 0.04 | 2.7 (2.0–3.8) | 1.4e-9 | ||
| Donor PRSs | ||||||||
| Donor hypertension PRS | −1.6 (0.32) | 6.7e-7 | 0.005 | −1.2 (0.49) | 0.02 | 0.002 | 1.07 (1.00–1.14) | 0.049 |
| Donor decreased eGFR PRS | −1.5 (0.32) | 5.4e-6 | 0.004 | −1.8 (0.5) | 4.4e-4 | 0.004 | 1.05 (0.99–1.13) | 0.11 |
| Donor albuminuria PRS | 0.52 (0.32) | 0.1 | 0.001 | −0.34 (0.5) | 0.5 | 0 | 1.00 (0.94–1.06) | 0.92 |
| Donor rapid eGFR decline PRS | −0.37 (0.38) | 0.34 | 0 | −0.15 (0.51) | 0.77 | 0 | 0.99 (0.92–1.06) | 0.73 |
| Donor intracranial aneurysm PRS | −1.03 (0.31) | 0.001 | 0.002 | −0.6 (0.48) | 0.21 | 0.001 | 1.04 (0.98–1.11) | 0.18 |
| Donor stroke PRS | −0.12 (0.31) | 0.7 | 0 | 0.58 (0.5) | 0.23 | 0 | 0.95 (0.89–1.01) | 0.09 |
| Donor decreased TKV PRS | 0.25 (0.31) | 0.43 | 0 | 0.08 (0.5) | 0.87 | 0 | 0.98 (0.92–1.05) | 0.58 |
| Recipient PRSs | ||||||||
| Recipient hypertension PRS | 0.53 (0.30) | 0.08 | 0 | 0.63 (0.49) | 0.2 | 0.001 | 0.99 (0.92–1.1) | 0.64 |
| Recipient decreased eGFR PRS | −1.5 (0.31) | 1.0e-6 | 0.004 | −1.1 (0.47) | 0.02 | 0.002 | 1.05 (0.99–1.1) | 0.09 |
| Recipient albuminuria PRS | 0.56 (0.32) | 0.08 | 0.001 | 0.14 (0.48) | 0.77 | 0 | 1.02 (0.96–1.1) | 0.5 |
| Recipient rapid eGFR decline PRS | 0.34 (0.36) | 0.35 | 0 | 0.65 (0.48) | 0.17 | 0.001 | 0.97 (0.91–1.0) | 0.4 |
| Recipient intracranial aneurysm PRS | 0.12 (0.32) | 0.7 | 0 | −0.43 (0.5) | 0.38 | 0 | 1.00 (0.94–1.1) | 0.97 |
| Recipient stroke PRS | −0.29 (0.32) | 0.36 | 0 | −0.83 (0.49) | 0.09 | 0.001 | 1.10 (0.99–1.1) | 0.12 |
| Recipient decreased TKV PRS | 0.1 (0.31) | 0.74 | 0 | 0.1 (0.49) | 0.83 | 0 | 0.94 (0.88–1.0) | 0.06 |
eGFR, estimated glomerular filtration rate; HR, hazard ratio; TKV, total kidney volume; SE, standard error.
Statistically significant (P < 0.05) predictors are bolded and italicised.