TABLE 3.
Multivariable models for recipient eGFR at 1- and 5-year post-transplant, and graft failure, keeping statistically significant factors from univariate models. Effect of polygenic risk scores is highlighted in grey.
| eGFR at 1-year (adjusted R2 = 0.26) | ||
|---|---|---|
| Estimate (95% CI) | P Value | |
| Intercept | −1,267 (−1,460, −1,098) | <2e-16 |
| Donor age | −0.54 (−0.59, −0.50) | <2e-16 |
| Male donor sex | 2.7 (1.5, 3.7) | 21.6e-6 |
| Male recipient sex | 1.68 (0.52, 2.72) | 0.004 |
| Recipient age | −0.25 (−0.29, −0.21) | <2e-16 |
| Year of transplant | 0.68 (0.59, 0.78) | <2e-16 |
| Donor type | ||
| Living | - | - |
| Stroke cause of death | −7.6 (−9.1, −6.2) | <2e-16 |
| Other cause of death | −6.3 (−7.8, −4.7) | <2e-16 |
| Donor albuminuria PRS | 0.24 (−0.32, 0.80) | 0.40 |
| Donor hypertension PRS | −1.3 (−1.7, −0.6) | 9.2e-6 |
| Donor decreased eGFR PRS | −1.2 (−1.8, −0.7) | 4.33e-5 |
| Donor intracranial aneurysm PRS | −0.66 (−1.2, −0.14) | 0.01 |
| Recipient hypertension PRS | 0.47 (−0.07, 1.02) | 0.09 |
| Recipient albuminuria PRS | −0.05 (−0.62, 0.50) | 0.85 |
| Recipient decreased eGFR PRS | −1.0 (−1.5, −0.49) | 0.001 |
| eGFR at 5-year (Adjusted R2 = 0.14) | ||
|---|---|---|
| Estimate (95% CI) | P value | |
| Intercept | −621 (−952, −290) | 0.0002 |
| Donor age | −0.68 (−0.7, −0.6) | <2e-16 |
| Male donor sex | 1.01 (−0.8, 2.9) | 0.28 |
| Recipient age | 0.04 (−0.0, 0.1) | 0.26 |
| Male recipient sex | 2.8 (0.9, 4.6) | 0.004 |
| Year of transplant | 0.35 (0.2, 0.5) | 3.7e-5 |
| HLA mismatch | −0.61 (−1.3, 0.1) | 0.09 |
| First transplant | 3.24 (0.7, 5.8) | 0.01 |
| Donor type | ||
| Living | - | - |
| Stroke cause of death | −8.0 (−11.8, −2.8) | 3.0e-5 |
| Other cause of death | −6.7 (−10.5, −2.8) | 0.0007 |
| Donor hypertension PRS | −0.7 (−1.9, −0.1) | 0.16 |
| Donor decreased eGFR PRS | −1.6 (−2.6, −0.8) | 0.0003 |
| Recipient decreased eGFR PRS | −0.9 (−1.8, −0.0) | 0.04 |
| Recipient stroke PRS | −0.95 (−1.9, −0.1) | 0.04 |
| Graft failure(R2 = 0.23) | ||
|---|---|---|
| HR (95% CI) | P value | |
| Donor age | 1.02 (1.02, 1.03) | 1.8e-13 |
| HLA mismatch | 1.13 (1.07, 1.19) | 3.3e-6 |
| First transplant | 0.61 (0.52, 0.72) | 6.1e-9 |
| Year of transplant | 0.97 (0.96, 0.98) | 2.3e-8 |
| Donor type | ||
| Living | - | - |
| Stroke cause of death | 2.6 (1.9, 3.6) | 8.7e-9 |
| Other cause of death | 2.5 (1.8, 3.5) | 5.6e-8 |
| Donor Hypertension PRS | 1.06 (0.99, 1.1) | 0.09 |
| Donor decreased eGFR PRS | 1.04 (0.98, 1.1) | 0.18 |
| Donor intracranial aneurysm PRS | 1.03 (0.96, 1.1) | 0.39 |
| Donor stroke PRS | 0.95 (0.90, 1.01) | 0.11 |
| Recipient decreased eGFR PRS | 1.05 (0.98, 1.11) | 0.15 |
| Recipient stroke PRS | 1.06 (0.98, 1.12) | 0.08 |
| Recipient decreased TKV PRS | 0.96 (0.90, 1.02) | 0.17 |
eGFR, estimated glomerular filtration rate; CI, confidence interval; HR, hazard ratio.