TABLE 3.

Association between aspirin treatment and mortality of patients with SALI.

Mortality	Model	HR (95% CI)	P value
30-day mortality	Unadjusted	0.67 (0.50 ∼ 0.91)	0.011
	PSM	0.57 (0.37 ∼ 0.90)	0.016
	Multivariate adjusted	0.69 (0.48 ∼ 0.99)	0.047
	IPW	0.62 (0.43 ∼ 0.89)	0.010
90-day mortality	Unadjusted	0.77 (0.59 ∼ 0.99)	0.049
	PSM	0.73 (0.50 ∼ 1.05)	0.091
	Multivariate adjusted	0.79 (0.58 ∼ 1.08)	0.141
	IPW	0.74 (0.54 ∼ 1.00)	0.051
ICU mortality	Unadjusted	0.53 (0.37 ∼ 0.76)	<0.001
	PSM	0.41 (0.24 ∼ 0.71)	0.001
	Multivariate adjusted	0.61 (0.39 ∼ 0.95)	0.030
	IPW	0.43 (0.28 ∼ 0.67)	<0.001
In-hospital mortality	Unadjusted	0.74 (0.55 ∼ 1.01)	0.058
	PSM	0.59 (0.37 ∼ 0.93)	0.024
	Multivariate adjusted	0.88 (0.61 ∼ 1.27)	0.491
	IPW	0.67 (0.47 ∼ 0.95)	0.024

Non-aspirin is reference. Multivariate adjusted: Adjusted for age, gender, race, platelets, albumin, INR, total bilirubin, ALP, AST, CCI, SOFA, score, SAPS II, score, hypertension; CAD, cerebrovascular, diabetes, AKI, RRT, vasopressor, and mechanical ventilation. SALI: Sepsis-associated liver injury; SOFA: sequential organ failure assessment; SAPS II: Simplified Acute Physiology Score II; INR: international normalized ratio; ALP: alkaline phosphatase; AST: aspartate aminotransferase; CCI: charlson comorbidity index; CAD: coronary artery disease; AKI: acute kidney injury; RRT: renal replacement therapy; PSM: propensity score matching; IPW: Inverse - Probability Weighting; ICU: intensive care unit; HR: hazard ratio; CI: Confidence Interval. P value <0.05 is considered statistical significance.