Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2025 Mar 4;15:1553511. doi: 10.3389/fonc.2025.1553511

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2025 AlKhazal, Chohan, Ross, Kim and Brown

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Preclinical evaluation of GPC2-targeting CAR T cells for neuroblastoma treatment. (A-C) show that GPC2-CAR T cells efficiently home to the tumor microenvironment (TME), expand, and enrich as a cytotoxic effector population, highlighting their potential for targeted tumor eradication. (D, E) compare the performance of GPC2-CAR T cells with GD2-CAR T cells (K666.28H.BBζ), showing superior in vitro cytotoxicity, tumor rechallenge response, and reduced tumor burden in vivo. Adapted from Sun et al., 2023, Journal for ImmunoTherapy of Cancer, 11(1):e005881 with permission from BMJ Specialist Journals.