Fig. 2.

Treatment process and disease development. A SOX 2 cycles, then developed a PD. B Radical esophageal resection in September 2022. C Postoperative adjuvant radiotherapy combined with capecitabine from November 2022. D Herbal treatment from March 2023 for 2 months. E Cadonilimab and trastuzumab therapy in our department. F Pyrotinib therapy, with a PFS of 7 months. PR partial response, CR complete response, PD progressive disease, SD Stable Disease, PFS progression-free survival, SOX oxaliplatin + tegafur