Table 1.
Effects of nicorandil treatment on antioxidant enzyme and lipid peroxidation in PUUO.
| Groups | Antioxidant enzyme activities | Lipid peroxidation MDA (pmol/μg protein) | ||
|---|---|---|---|---|
| GSH‐PX (mIU/μg protein) | SOD (pg/μg protein) | CAT (mIU/μg protein) | ||
| Sham‐control (Group 1, n = 10) | 0.31 ± 0.002 | 0.30 ± 0.002 | 2.26 ± 0.010 | 5.1 ± 0.30 |
| PUUO‐untreated (Group 2, n = 10) | 0.28 ± 0.004* | 0.27 ± 0.003* | 2.08 ± 0.020* | 12.9 ± 0.41 |
| PUUO‐nicorandil (Group 3, n = 10) | 0.36 ± 0.011† | 0.34 ± 0.010† | 2.65 ± 0.088† | 7.6 ± 0.32 |
CAT = catalase; GSH‐Px = glutathione peroxidase; MDA = malondialdehyde; PUUO = partial unilateral ureteral obstruction; SOD = superoxide dismutase.
*Group 2 versus Group 1, p < 0.05; Group 2 versus Group 3, p < 0.0001.
†SOD, CAT, and GSH‐Px levels were increased in Group 3. Group 2 versus Group 3, p < 0.0001.
Group 2 versus Group 1, p < 0.05; Group 2 versus Group 3, p < 0.0001.
The MDA levels were decreased in Group 3. Group 2 versus Group 3, p < 0.0001.