Table 3.
Maternal demographics and clinical characteristics stratified by case–control status
| HDP | SEVERE PE/HELLP SYNDROME | |||||||
|---|---|---|---|---|---|---|---|---|
| Variable | N | Cases (n = 143) |
N | Controls (n = 169) |
N | Cases (n = 99) |
N | Controls (n = 31) |
| Age | 142 | 27.9 ± 7.4 | 169 | 26.8 ± 7.0 | 98 | 31.0 ± 4.1 | 27 | 32.1 ± 4.0 |
| Hispanic race (%) | 142 | 138 (97.2) | 169 | 164 (97.0) | – | NA | – | NA |
| White race (%) | – | NA | – | NA | 98 | 97 (99.0) | 28 | 28 (100.0) |
| Gestational age at delivery (weeks) | 142 | 36.8 ± 3.3 | 168 | 38.7 ± 2.0 | 96 | 33.1 ± 4.1 | 20 | 39.6 ± 1.8 |
| Pre-pregnancy weight (lbs) | 143 | 151.9 ± 36.0 | 169 | 140.0 ± 27.1 | 81 | 147.5 ± 32.0 | – | NA |
| Max systolic blood pressure (mmHg) | 134 | 162.9 ± 15.7 | 159 | 117.9 ± 10.9 | 92 | 159.6 ± 22.0 | – | NA |
| Max diastolic blood pressure (mmHg) | 134 | 97.4 ± 9.9 | 159 | 68.9 ± 9.0 | 92 | 97.6 ± 13.4 | – | NA |
| Nulliparity (%) | 142 | 168 | 96 | 23 | ||||
| Nulliparous | 61 (43.0) | 52 (31.0) | 83 (86.5) | 12 (52.2) | ||||
| Parous | 81 (57.0) | 116 (69.0) | 13 (13.4) | 11 (47.8) | ||||
| Gravidity (%) | 142 | 169 | 92 | 21 | ||||
| 1 | 50 (35.2) | 43 (25.4) | 68 (73.9) | 10 (47.6) | ||||
| 2 | 34 (23.9) | 48 (29.0) | 16 (17.4) | 6 (28.6) | ||||
| 3 | 20 (14.1) | 30 (17.8) | 5 (5.4) | 3 (14.3) | ||||
| 4 or more | 38 (26.8) | 47 (27.8) | 3 (3.3) | 2 (9.5) | ||||
| Status | – | – | 99 | – | ||||
| Severe PE | NA | NA | 56 (56.6) | NA | ||||
| HELLP | NA | NA | 43 (43.4) | NA | ||||
| Lactate dehydrogenase, U/L (IQR) | – | NA | – | NA | 52 |
601.5 (334, 1170) |
– | NA |
| Bilirubin, mg/dL (IQR) | – | NA | – | NA | 67 |
1 (0.6, 2.1) |
– | NA |
| Aspartate aminotransferase, U/L (IQR) | – | NA | – | NA | 88 |
282 (129, 468) |
– | NA |
| Alanine aminotransferase, U/L (IQR) | – | NA | – | NA | 84 |
231 (137, 382) |
– | NA |
| Creatinine,mg/dL (IQR) | – | NA | – | NA | 77 |
0.8 (0.7, 1.0) |
- | NA |
| Platelet count, 10^9/L (IQR) | – | NA | – | NA | 90 |
58.5 (37.2, 89.6) |
– | NA |
| Birthweight, grams (IQR) | 127 |
3060 (2400, 3462) |
159 |
3295 (3025, 3600) |
83 |
1955 (1238, 2728) |
– | NA |
| Fetal growth restriction (%) | 135 | 16 (11.9) | 169 | 10 (5.9) | 89 | 10 (11.2) | – | NA |
| Gestational diabetes (%) | 141 | 70 (49.6) | 163 | 66 (40.5) | 90 | 7 (7.8) | – | NA |