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. 2025 Mar 18;20(1):27. doi: 10.1007/s11481-025-10188-4

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 8 — Effects of SE, AST, and PHA on PERK/GRP78/CHOP and BAX/Bcl-2 signaling pathways in MSG-intoxicated rats: (A) PERK, (B) GRP78, (C) CHOP, (D) BAX and (E) Bcl-2. The data are presented as means ± S.E.M (n = 6). Significance (a): relative to the control group, (b): relative to MSG group, (c): relative to PHA + MSG, (d): relative to SE + MSG, (e): relative to AST + MSG, and (f): relative to SE + AST + MSG. P-value < 0.05. Monosodium glutamate (MSG); Physical activity (PHA); Sesamol (SE); Astaxanthin (AST); COMB (SE + AST + PHA); Protein kinase RNA-like ER kinase (PERK), Glucose-regulated protein 78 (GRP78), Pro-apoptotic C/EBP homologous protein (CHOP), Bcl-2-associated X protein (BAX), B-cell lymphoma 2 protein (Bcl-2)