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. 2025 Mar 20;25:78. doi: 10.1186/s12874-025-02520-6

Table 2.

Decision boundaries applied on the posterior probability of H1 for the early stopping in the Bayesian group sequential design

Analysis Futility Stopping Continuation Region Efficacy Stopping
1 Pr(H1) < 0.337 0.337 ≤ Pr(H1) ≤ 0.997 Pr(H1)  > 0.997
2 Pr(H1) < 0.739 0.739 ≤ Pr(H1) ≤ 0.989 Pr(H1) > 0.989
f - - Pr(H1) > 0.949