Table 3.

Hazard ratio of sleep apnea for DAT

	Women		Men
	HR (95% CI)*	p	HR (95% CI)*		p		p for interaction by sex**
Sleep apnea	1.30 (1.16–1.44)	< 0.001	1.13 (1.03–1.24)		0.012		0.015
Sleep apnea subtype
Obese sleep apnea	1.39 (1.21–1.58)	< 0.001	1.06 (0.94–1.20)		0.329		0.002
	Entire study population
	HR (95% CI)*			p		p for interaction by sex**
Non-obese sleep apnea	1.18 (1.07–1.30)			< 0.001		0.667

*Adjusted HR for DAT was obtained using Cox proportional hazards regression with sleep apnea or sleep apnea subtype as a predictor after controlling for age, sex, obesity, hypertension, diabetes, hyperlipidemia, ischemic stroke, hemorrhagic stroke, coronary heart disease, physical inactivity, heavy alcohol consumption, and smoking status in each sex. Obesity was excluded as a covariate in the analysis with sleep apnea subtype as a predictor

**p for interaction was estimated by the Cox proportional hazards regressions including sleep apnea or sleep apnea subtype and sex together as main effects and sex*sleep apnea or sex*sleep apnea subtype as an interaction effect after controlling for the same potential confounders in the entire study population

Abbreviations: CI, confidence interval; DAT, dementia of the Alzheimer type; HR, hazard ratio