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| PAMPA | PPB | PPB | ||||
|---|---|---|---|---|---|---|
| compound | Pe [10–6 ± SD cm/s] | KD [μM] | fb [% ± SD] | metabolic stabilitya [% remaining] | neurotoxicity [IC50, μM] | hepatotoxicity [IC50, μM] |
| SSR504734 | 14.80 ± 1.49 | 8.04 | 98.7 ± 0.13 | 94.72 | 38.05 | 14.75 |
| reference drugs | caffeine | warfarin | warfarin | verapamil | doxorubicin | doxorubicin |
| 7.77 ± 2.30 | 9.50 | 98.5 ± 2.10 | 30.84 | 0.30 | 1.91 |
After 120 min of incubation with human liver microsomes.
