Table 1.

The metabolite mediation effect

Immune cell	Metabolite	Outcome	Mediated effect	Mediated proportion	P value
HLA DR + CD4 + AC	Bilirubin degradation product, C16H18N2O5 (3) levels	Head and neck cancer	0.0193 (0.00281, 0.0358)	7.17% (1.04%, 13.3%)	0.022
EM CD8br AC	Glutamine to alanine ratio	Head and neck cancer	0.0275 (0.00682, 0.0482)	8.88%(2.2%, 15.6%)	0.009

Bold values signify P <0 .05