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. 2025 Mar 21;31:110. doi: 10.1186/s10020-025-01142-4

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Comprehensive Multi-omics Analysis of Transcriptional Activity Dynamics in Schwann Cells Following Runx2 Overexpression (Runx2-OE). Heatmap visualization depicting the spatial distribution of chromatin accessibility (ATAC) and histone modifications (H3K27ac, H3K27me3) relative to transcription start sites (TSS) across distinct regulatory states after Runx2-OE. Regulatory states are classified as Active (A), Repressed (R), or Silent (S). Red boxes highlight gene sets transitioning from Repressed to Active (RA) or Silent to Active (SA) states. Venn diagram illustrating the intersection of three gene sets, including genes transitioning from Repressed to Active (RA), genes transitioning from Silent to Active (SA), upregulated genes following Runx2 overexpression (OE_NGS). Red circle emphasizes the overlapping gene subset. C-E) Functional characterization of genes co-identified in SA and OE_NGS intersections. C Gene Ontology (GO) enrichment analysis. Circle size correlates with the number of differentially expressed genes per category. Color intensity (darker red) indicates statistical significance (p-value). D KEGG pathway enrichment analysis. Circle size represents the number of differentially expressed genes per pathway. Color gradient reflects statistical significance. E Representative genome browser view (IGV) of the Wnt5a locus (scale bar = 10 kb). Blue represents the EGFP group, red bands represent the Runx2-OE group, and gray areas indicate regions with dramatic peak changes between different tracks