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. 2025 Mar 19;13:e19072. doi: 10.7717/peerj.19072

Figure 2. Aberrantly activated TGF BETA signaling pathway in cervical cancer fibroblasts promotes proliferation.

Figure 2

(A) Fibroblast TGF BETA SIGNALING AUCell score in normal and tumor groups. (B) Expression of TGF BETA SIGNALING-related genes in fibroblasts in normal and tumor groups. (C–D) Proposed time-series analysis of fibroblasts. (E) Cell density distribution of fibroblasts with pseudo-timeline in normal and CC groups. (F) The expression heatmap of TGF BETA SIGNALING related genes on the pseudo-time trajectory. (G) The expression heatmap of fibroblast proliferation characterized genes with pseudo-timeline trajectories. (H) Heatmap of cell proliferation characterized genes expression level with pseudo-timeline trajectory. (I) Expression heatmap of cell cycle characterized genes with pseudo-timeline trajectories. (J) Violin plot of expressions of apoptosis inhibition related genes in high and low TGF BETA SIGNALING score groups. (K) Violin plot of expressions of cell proliferation-related genes in the two subgroups.