Figure 12.

Comparative analysis of Deiters’ cell and pillar cell (inner and outer pillar cell) susceptibility to cyclodextrin treatment. (A) In the apical and middle regions, there are no significant differences in the percentage loss of Deiters’ cells (DC) and pillar cells (PC). Each dot represents data from one confocal image, and the data was obtained from the analysis of 10 cochleae. ** indicates p < 0.01. (B) In the basal region of the cochlea, pillar cells exhibit a significantly greater loss compared to Deiters’ cells. Each dot represents data from one confocal image, and the data was obtained from the analysis of 10 cochleae. (C) The image shows the juncture of the organ of Corti between the region with complete loss of pillar cells (marked by asterisks) and the region with surviving pillar cells marked by the double-arrow. Notice that Deiters’ cells are present (arrows) in the region where both inner and outer pillar cells are completely lost, highlighting the increased vulnerability of pillar cells to cyclodextrin-induced damage.