Table 2.
Associations between the inflammatory-immune markers with atrial fibrillation, heart failure and CVD mortality.
| Atrial fibrillation(n = 16,994) | Heart failure(n = 7342) | CVD mortality(n = 3434) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | Model 1 | Model 2 | |||||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| NLR | ||||||||||||
| 1st | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| 2nd | 1.07 (1.02, 1.12) | 0.006 | 1.02 (0.97,1.06) | 0.517 | 1.14 (1.06, 1.22) | < 0.001 | 1.10 (1.02, 1.18) | 0.010 | 1.14 (1.02, 1.26) | 0.020 | 1.04 (0.93, 1.16) | 0.493 |
| 3rd | 1.19 (1.14, 1.24) | < 0.001 | 1.09 (1.04, 1.13) | < 0.001 | 1.28 (1.19, 1.37) | < 0.001 | 1.19 (1.11, 1.27) | < 0.001 | 1.36 (1.23, 1.51) | < 0.001 | 1.17 (1.05, 1.29) | 0.004 |
| 4th | 1.36 (1.30,1.42) | < 0.001 | 1.18 (1.13, 1.24) | < 0.001 | 1.62 (1.51, 1.72) | < 0.001 | 1.42 (1.33, 1.52) | < 0.001 | 1.93 (1.75, 2.12) | < 0.001 | 1.44 (1.30, 1.58) | < 0.001 |
| MLR | ||||||||||||
| 1st | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| 2nd | 1.12 (1.06, 1.17) | < 0.001 | 1.02 (0.97, 1.07) | 0.400 | 1.03 (0.95, 1.10) | 0.502 | 0.98 (0.91, 1.05) | 0.584 | 1.19 (1.06, 1.33) | 0.002 | 1.08 (0.96, 1.21) | 0.191 |
| 3rd | 1.28 (1.23, 1.34) | < 0.001 | 1.08 (1.03, 1.14) | < 0.001 | 1.29 (1.11, 1.28) | < 0.001 | 1.06 (0.99, 1.14) | 0.117 | 1.49 (1.34, 1.65) | < 0.001 | 1.14 (1.03, 1.28) | 0.016 |
| 4th | 1.56 (1.49, 1.63) | < 0.001 | 1.19 (1.14, 1.25) | < 0.001 | 1.57 (1.47, 1.68) | < 0.001 | 1.28 (1.19, 1.37) | < 0.001 | 2.40 (2.17, 2.64) | < 0.001 | 1.46 (1.31, 1.61) | < 0.001 |
| SII | ||||||||||||
| 1st | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| 2nd | 0.93 (0.89, 0.97) | 0.001 | 0.93 (0.89, 0.97) | < 0.001 | 0.98 (0.92, 1.04) | 0.550 | 1.00 (0.93, 1.06) | 0.887 | 0.97 (0.87, 1.07) | 0.488 | 0.98 (0.89, 1.09) | 0.744 |
| 3rd | 0.98 (0.94, 1.02) | 0.263 | 0.97 (0.93, 1.01) | 0.165 | 1.08 (1.01, 1.15) | 0.020 | 1.09 (1.02, 1.17) | 0.008 | 1.04 (0.95, 1.15) | 0.398 | 1.06 (0.96, 1.17) | 0.223 |
| 4th | 1.04 (1.00, 1.09) | 0.062 | 1.01 (0.97, 1.06) | 0.576 | 1.27 (1.19, 1.35) | < 0.001 | 1.24 (1.16, 1.32) | < 0.001 | 1.39 (1.27, 1.52) | < 0.001 | 1.36 (1.24, 1.49) | < 0.001 |
| SIRI | ||||||||||||
| 1st | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| 2nd | 1.13 (1.08, 1.19) | < 0.001 | 1.02 (0.97, 1.07) | 0.411 | 1.21 (1.12, 1.31) | < 0.001 | 1.10 (1.01, 1.19) | 0.020 | 1.30 (1.16, 1.47) | < 0.001 | 1.06 (0.94, 1.19) | 0.358 |
| 3rd | 1.34 (1.29, 1.40) | < 0.001 | 1.10 (1.05, 1.16) | < 0.001 | 1.48 (1.37, 1.59) | < 0.001 | 1.21 (1.12, 1.30) | < 0.001 | 1.80 (1.61, 2.02) | < 0.001 | 1.23 (1.10, 1.37) | < 0.001 |
| 4th | 1.67 (1.60, 1.74) | < 0.001 | 1.22 (1.16, 1.27) | < 0.001 | 2.07 (1.94, 2.22) | < 0.001 | 1.45 (1.35, 1.56) | < 0.001 | 3.09 (2.79, 3.42) | < 0.001 | 1.57 (1.41, 1.75) | < 0.001 |
| AISI | ||||||||||||
| 1st | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| 2nd | 1.04 (1.00, 1.09) | 0.069 | 0.98 (0.94, 1.03) | 0.378 | 1.10 (1.03, 1.19) | 0.008 | 1.05 (0.97, 1.12) | 0.235 | 1.30 (1.17, 1.46) | < 0.001 | 1.14 (1.02, 1.28) | 0.020 |
| 3rd | 1.16 (1.11, 1.21) | < 0.001 | 1.02 (0.97, 1.07) | 0.420 | 1.27 (1.18, 1.36) | < 0.001 | 1.11 (1.03, 1.19) | 0.004 | 1.60 (1.43, 1.78) | < 0.001 | 1.24 (1.12, 1.39) | < 0.001 |
| 4th | 1.34 (1.28, 1.40) | < 0.001 | 1.08 (1.03, 1.13) | < 0.001 | 1.72 (1.61, 1.83) | < 0.001 | 1.32 (1.23, 1.41) | < 0.001 | 2.43 (2.20, 2.69) | < 0.001 | 1.57 (1.41, 1.73) | < 0.001 |
Model 1 unadjusted.
Model 2 was adjusted for age,sex, race, smoking, alcohol consumption,sedentary time, healthy diet pattern, body mass index, Townsen index, systolic blood pressure, diastolic blood pressure, diabetes mellitus, coronary heart disease, anti-hypertension drugs, cholesterol lower drugs, and aspirin.
NLR neutrophil to lymphocyte ratio, MLR monocyte to lymphocyte ratio, SII systemic inflammation index, SIRI systemic inflammation response index, AISI the aggregate index of systemic inflammation, CVD cardiovascular disease.