Fig 2.

L. plantarum ATCC 202195 (LP202195), when administered to neonates in Dhaka, Bangladesh, for 1 or 7 days, with or without FOS, does not result in LP202195 colonization. (A) Longitudinal trajectories of LP202195 AA (cells/µg DNA) modeled as a function of days since first IP dose, up to 180 days since first dose, and (B) zooming in on the trajectories within the first 28 days since first IP dose. (C) Differences in AA of LP202195 (log₁₀ cells/µg DNA) across intervention groups, relative to the placebo group, are shown at discrete time points between 8 and 60 days since first IP dose. The vertical dashed blue line at 32 days since first dose indicates the time point at which the AA in the LP1 group was no longer significantly different from the AA in the placebo group. The vertical dashed red line at 60 days since first dose indicates the time point at which the AAs LP1 + FOS, LP7, and LP7 + FOS groups were no longer significantly different from the AA in the placebo group. (D) Predicted probabilities of high versus low AA of LP202195, by days since first dose. In each panel, the placebo group is shown with a black solid line, the LP1 group with the light blue solid line, the LP1 + FOS group with a dashed light blue line, the LP7 group with a solid red line, and the LP7 + FOS group with a dashed red line.