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Effects of fraction BW and diphenhydramine on vascular permeability increase caused by PCA and histamine in male ddY mice. Vascular permeability increase was cause by PCA (A) and histamine injection (B) in the mouse ear. BW and diphenhydramine were administered orally 1 h and 30 min, respectively, before eliciting the reaction. Each value represents the mean ± SEM for three or seven mice. *P < 0.05, **P < 0.01.
