TABLE 3.

Correlations between cross-clade T-cell responses and sequence diversity in patient-specific HLA class I documented Gag and Nef CTL epitopes

Type of cross-clade T-cell responses (clades A, B, and C)	Parameter	p distance epitopes	p distance no HLA anchors	p distance HLA anchors −1	p distance external to CTL epitopes
Gag	Spearman r	−0,543	−0,209	−0,703	−0.226
	95% confidence interval	(−0.839-<0.001)	(−0.676-0.377)	(−0.902-−0.259)	(−0.685-0.361)
	P value (two tailed)	0.045	0.472	0.005	0.436
Nef	Spearman r	−0,864	−0,848	−0,747	0,252
	95% confidence interval	−0.963-−0.563	−0.958-−0.520	−0.928-−0.286	(−0.393-0.731)
	P value (two tailed)	0.001	0.001	0.007	0.430