TABLE 1.
Frequencies and numbers of macrophages and neutrophils in the CNS
| Virus and group (n)a | Starting no. (105) | Macrophages
|
Neutrophils
|
||
|---|---|---|---|---|---|
| % | No. (104) | % | No. (104) | ||
| rJ2.2.6 | |||||
| Day 1.5 (6) | 7.5 ± 1.3 | 47.2 ± 4.9 | 7.8 ± 2.7 | 9.7 ± 1.5 | 1.4 ± 0.3 |
| Day 3 (6) | 7.5 ± 1.0 | 33.6 ± 3.3 | 14 ± 3.0 | 32.6 ± 5.3b | 12 ± 3.0b |
| Day 6 (4) | 12 ± 2.0 | 12.7 ± 0.8 | 7.6 ± 2.2 | 4.8 ± 1.0b | 2.5 ± 0.4b |
| rJ2.2.6trunc&KO | |||||
| Day 1.5 (6) | 4.5 ± 0.6 | 42.6 ± 2.6 | 4.7 ± 1.0 | 12.8 ± 2.7 | 1.6 ± 0.6 |
| Day 3 (10) | 5.8 ± 0.8 | 32.7 ± 2.8 | 6.7 ± 2.3 | 14.7 ± 2.5 | 2.7 ± 0.9 |
| Day 6 (6) | 13 ± 1.0 | 21.2 ± 2.9 | 16 ± 3.0 | 2.5 ± 0.3 | 1.8 ± 0.2 |
a
Number of individual mice analyzed.
b
Increased neutrophils (frequency and number) were present in the rJ2.2.6-infected CNS at day 3 (P < 0.005) and day 6 p.i. (P < 0.05 for the frequency; P = 0.13 for the number). Values are means ± SEM.