Table 1.
Latency (in seconds) to first press is not significantly altered by ibogaine or GDNF treatment a
|
Experiment |
Mean ± SEM |
Median (minimum, maximum) |
|---|---|---|
| Ethanol self-administration | ||
| Intraperitoneal vehicle | 113.4 ± 48.3 | 67.4 (7.5, 439.4) |
| Intraperitoneal ibogaine | 86.6 ± 17.8 | 86.6 (13.6, 191.4) |
| Ethanol relapse | ||
| Intraperitoneal vehicle | 411.6 ± 139.4 | 427.5 (21.8,248.7) |
| Intraperitoneal ibogaine | 163.0 ± 54.7 | 106.0 (27.6,461.9) |
| Ethanol self-administration | ||
| Intra-VTA ACSF | 102.95 ± 19.23 | 98.78 (33.7,207.1) |
| Intra-VTA ibogaine (10 μm) | 92.69 ± 22.14 | 63.71 (17.1,205.5) |
| Ethanol self-administration | ||
| Intra-VTA ACSF | 176.43 ± 27.10 | 153.98 (27.6,295.6) |
| Intra-VTA GDNF |
169.70 ± 30.23 |
145.75 (64.8,312.7) |
a
Wilcoxon matched-pairs test; all p > 0.05.