Table 3.
MR analysis and sensitivity analyses for causality from upper urinary stones on 12 blood metabolites
| Name | Outcome | Metabolites | Number of SNPs | MR analysis | Heterogeneity | Pleiotropy | MR-PRESSO | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Method | OR (95% CI) | Lower CI | Upper CI | P | IVW | MR Egger | Intercept | P | P | ||||||
| Q | P | Q | P | ||||||||||||
| 1-methyl-4-imidazoleacetate | GCST90199717 | Azoles | 55 | IVW | 1.03 | 0.98 | 1.09 | 0.2144 | 53.45 | 0.4954 | 53.27 | 0.4638 | ‐0.0031 | 0.6695 | 0.2175 |
| Mannose | GCST90200435 | Carbohydrate | 55 | IVW | 1.06 | 1.00 | 1.13 | 0.0449 | 66.38 | 0.1202 | 66.33 | 0.1033 | 0.0018 | 0.8325 | 0.1154 |
| 1-linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6) | GCST90200073 | Lipid | 55 | IVW | 0.96 | 0.91 | 1.01 | 0.1403 | 53.69 | 0.4864 | 53.69 | 0.4478 | 0.0002 | 0.9787 | 0.1449 |
| Eicosenedioate (C20:1-DC) | GCST90200285 | Lipid | 55 | IVW | 1.02 | 0.96 | 1.08 | 0.5097 | 53.53 | 0.4923 | 51.73 | 0.5237 | 0.0101 | 0.1850 | 0.5107 |
| 1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6) | GCST90200065 | Lipid | 55 | IVW | 1.04 | 0.99 | 1.10 | 0.1236 | 51.11 | 0.5867 | 51.07 | 0.5495 | 0.0013 | 0.8596 | 0.1193 |
| 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | GCST90200331 | Lipid | 55 | IVW | 1.05 | 0.99 | 1.11 | 0.1123 | 56.21 | 0.3921 | 56.07 | 0.3604 | 0.0028 | 0.7197 | 0.1182 |
| 1-oleoyl-2-arachidonoyl-GPE (18:1/20:4) | GCST90200079 | Lipid | 55 | IVW | 1.00 | 0.95 | 1.05 | 0.9470 | 49.11 | 0.6629 | 49.11 | 0.6263 | -0.0004 | 0.9565 | 0.9447 |
| Adenosine 5’-monophosphate (AMP) | GCST90200356 | Nucleotide | 55 | IVW | 0.98 | 0.93 | 1.03 | 0.4519 | 55.80 | 0.4070 | 55.79 | 0.3704 | -0.0007 | 0.9217 | 0.4552 |
| Cysteinylglycine | GCST90200364 | Peptide | 55 | IVW | 0.98 | 0.93 | 1.03 | 0.4040 | 48.16 | 0.6981 | 47.92 | 0.6716 | -0.0036 | 0.6306 | 0.3808 |
| Urea | GCST90200417 | Ureas | 55 | IVW | 1.05 | 0.99 | 1.11 | 0.1282 | 63.49 | 0.1768 | 63.34 | 0.1563 | 0.0027 | 0.7306 | 0.1341 |
| X-17654 | GCST90200547 | Unknown | 55 | IVW | 0.97 | 0.92 | 1.02 | 0.2403 | 40.55 | 0.9123 | 40.54 | 0.8951 | -0.0004 | 0.9547 | 0.1811 |
| X-19141 | GCST90200711 | Unknown | 55 | IVW | 1.00 | 0.94 | 1.05 | 0.8769 | 48.62 | 0.6811 | 48.47 | 0.6511 | 0.0029 | 0.6936 | 0.2175 |
CI = confidence interval, IVW = inverse variance weighted, MR = Mendelian randomization, MR-PRESSO = MR-Pleiotropy RESidual sum and outlier, OR = odds ratio, SNPs = single nucleotide polymorphisms.