Table 4.
MR analysis and sensitivity analyses for causality from lower urinary stones on 12 blood metabolites.
| Name | Outcome | Metabolites | Number of SNPs | MR analysis | Heterogeneity | Pleiotropy | MR-PRESSO | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Method | OR (95% CI) | Lower CI | Upper CI | P | IVW | MR Egger | Intercept | P | P | ||||||
| Q | P | Q | P | ||||||||||||
| 1-methyl-4-imidazoleacetate | GCST90199717 | Azoles | 11 | IVW | 1.01 | 0.98 | 1.03 | 0.5667 | 12.01 | 0.2847 | 8.45 | 0.4898 | -0.0183 | 0.0919 | 0.5793 |
| Mannose | GCST90200435 | Carbohydrate | 11 | IVW | 1.01 | 0.98 | 1.04 | 0.6419 | 20.15 | 0.0279 | 19.80 | 0.0192 | -0.0059 | 0.7012 | 0.6519 |
| 1-oleoyl-2-arachidonoyl-GPE (18:1/20:4) | GCST90200079 | Lipid | 11 | IVW | 1.03 | 1.00 | 1.05 | 0.0238 | 6.98 | 0.7274 | 4.91 | 0.8423 | -0.0148 | 0.1840 | 0.5178 |
| 1-linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6) | GCST90200073 | Lipid | 11 | IVW | 0.99 | 0.97 | 1.02 | 0.5510 | 12.72 | 0.2398 | 12.49 | 0.1870 | 0.0048 | 0.6941 | 0.5643 |
| 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | GCST90200331 | Lipid | 11 | IVW | 1.01 | 0.98 | 1.04 | 0.5139 | 18.03 | 0.0544 | 10.29 | 0.3279 | ‐0.0284 | 0.0286 | 0.5286 |
| 1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6) | GCST90200065 | Lipid | 11 | IVW | 1.03 | 1.01 | 1.05 | 0.0097 | 6.91 | 0.7343 | 6.53 | 0.6863 | ‐0.0061 | 0.5534 | 0.5392 |
| Eicosenedioate (C20:1-DC) | GCST90200285 | Lipid | 11 | IVW | 0.99 | 0.97 | 1.01 | 0.2391 | 7.92 | 0.6368 | 7.90 | 0.5443 | 0.0014 | 0.8926 | 0.2153 |
| Adenosine 5’-monophosphate (AMP) | GCST90200356 | Nucleotide | 11 | IVW | 1.00 | 0.98 | 1.02 | 0.8203 | 3.32 | 0.9728 | 3.32 | 0.9503 | 0.0004 | 0.9704 | 0.7017 |
| Cysteinylglycine | GCST90200364 | Peptide | 11 | IVW | 0.99 | 0.97 | 1.01 | 0.2056 | 5.91 | 0.8229 | 4.82 | 0.8499 | ‐0.0105 | 0.3236 | 0.1307 |
| Urea | GCST90200417 | Ureas | 11 | IVW | 1.00 | 0.98 | 1.02 | 0.7455 | 10.01 | 0.4399 | 9.75 | 0.3712 | 0.0050 | 0.6372 | 0.7522 |
| X-17654 | GCST90200547 | Unknown | 11 | IVW | 1.00 | 0.98 | 1.02 | 0.8169 | 9.83 | 0.4553 | 9.81 | 0.3662 | 0.0016 | 0.8859 | 0.8201 |
| X-19141 | GCST90200711 | Unknown | 11 | IVW | 1.01 | 0.99 | 1.03 | 0.5551 | 8.31 | 0.5983 | 8.25 | 0.5096 | 0.0026 | 0.8007 | 0.5320 |
CI = confidence interval, IVW = inverse variance weighted, MR = Mendelian randomization, MR-PRESSO = MR-Pleiotropy RESidual sum and outlier, OR = odds ratio, SNPs = single nucleotide polymorphisms.