Fig. 3.

Ethanol-induced CPP is not altered in Fyn^−/− compared with Fyn^+/+mice. Mice were bred on a primarily 129 background. Conditioning was performed with 2.0 g/kg ethanol (intraperitoneally) as described in “Materials and Methods.” Both Fyn^−/− and Fyn^+/+ show significant CPP (p < 0.01, paired t test); however, there was no significant difference in the net time that Fyn^+/+ mice (white bar) and Fyn^−/− mice (black bar) spent in the ethanol-paired compartment (t test, p = 0.81). The number of animals tested is shown in parentheses.