Fig. 4.

Fyn^−/− and Fyn^+/+ mice bred on a primarily C57 background show similar LORR and ethanol consumption and preference phenotypes as Fyn(129) mice. (A) Ethanol sensitivity was evaluated by measuring the duration of LORR after administration of sedative doses of ethanol. Fyn^−/− mice (black bars) showed a dose-dependent increase in the duration of LORR compared with Fyn^+/+ control mice (white bars) when mice were bred on a primarily C57 background [F(1,14)(genotype) = 10.3, p < 0.006; F(1,11)(dose) = 15.0, p < 0.003; F(dose × genotype), not significant]. (B) Voluntary ethanol intake (g/kg) plotted as a function of ethanol concentration as in Fig. 2. (C) Ethanol preference was calculated as in Fig. 2. Fyn^−/− mice demonstrated no significant alteration in ethanol consumption or preference compared with Fyn^+/+ littermates. The number of animals tested is shown in parentheses on the top of each histogram. Data are presented as mean ± SEM, and groups were compared by two-way repeated-measures ANOVA. *p = 0.05 and **p = 0.01 relative to wild-type littermates, Tukey’s test.