Table 2.

Objective adherence moderation models (MEMS Caps, n = 83)

Parameters	Conditional model: main effects	Interaction model: condition × time	Interaction model: age	Interaction model: anxiety Sx	Interaction model: depressive Sx	Interaction model: symptom Distress	Interaction model: AET concerns
Regression coefficients (fixed effects)
Intercept	90.89 (3.89)*** [83.37, 98.43]	91.52 (4.34)*** [83.12, 99.97]	93.43 (21.54)*** [52.22, 124.87]	103.87 (7.99)*** [88.50, 119.20]	99.12 (6.04)*** [87.52, 110.72]	87.69 (9.36)*** [69.70, 105.71]	97.89 (16.31)*** [66.63, 129.31]
Time	−1.46 (1.10) [−3.63, 0.70]	−1.83 (1.57) [−4.91, 1.25]	2.35 (8.36) [−13.82, 18.52]	−6.61 (3.36)+ [−13.12, −0.10]	−3.52 (2.50) [−8.35, 1.32]	−1.31 (4.01) [−9.07, 6.44]	0.43 (6.73) [−12.58, 13.45]
Distress	−2.65 (3.39) [−9.22, 3.91]	−2.65 (3.39) [−9.22, 3.91]	−2.59 (3.53) [−9.34, 4.16]	0.41 (5.50) [−10.16, 10.97]	−0.39 (3.90) [−7.84, 7.06]	−3.26 (3.58) [−10.09, 3.59]	−3.19 (3.47) [−9.84, 3.46]
Ovarian suppression	0.63 (4.10) [−7.31, 8.57]	0.63 (4.10) [−7.31, 8.57]	−0.72 (4.67) [−9.67, 8.22]	1.35 (4.21) [−6.71, 9.41]	0.82 (4.10) [−7.01, 8.65]	0.34 (4.17) [−7.62, 8.30]	0.25 (4.17) [−7.73, 8.23]
Condition	5.71 (3.55)+ [−1.16, 12.59]	4.46 (5.21) [−5.69, 14.61]	9.14 (30.30) [−49.17, 67.28]	−15.80 (10.52)+ [−36.01, 4.44]	−14.36 (8.59)+ [−30.88, 2.16]	1.06 (12.30) [−22.61, 24.73]	17.93 (20.48) [−21.51, 57.24]
Moderator	-	-	−0.03 (0.37) [−0.75, 0.69]	−1.96 (1.14)+ [−4.13, 0.24]	−1.88 (1.02)+ [−3.84, 0.08]	0.19 (0.39) [−0.56, 0.95]	−0.41 (1.05) [−2.44, 1.62]
Condition × time	-	0.72 (2.21) [−3.60, 5.05]	−12.47 (12.57) [−36.78, 11.84]	9.79 (4.53)* [1.03, 18.55]	8.25 (3.68)* [1.14, 15.36]	3.73 (5.32) [−6.56, 14.02]	−12.54 (8.63)+ [−29.23, 4.16]
Condition × moderator	-	-	−0.09 (0.53) [−1.10, 0.93]	2.75 (1.24)* [0.36, 5.12]	4.10 (1.51)** [1.20, 7.00]	0.18 (0.53) [−0.84, 1.21]	−0.94 (1.35) [−3.54, 1.66]
Time × moderator	-	-	−0.08 (0.15) [−0.37, 0.22]	0.66 (0.41)+ [−0.14, 1.46]	0.36 (0.43) [−0.46, 1.19]	−0.02 (0.17) [−0.35, 0.30]	−0.15 (0.45) [−1.02, 0.71]
Condition × time × moderator	-	-	0.23 (0.22) [−0.19, 0.66]	−1.20 (0.53)* [−2.23, −0.18]	−1.65 (0.65)* [−2.92, −0.39]	−0.15 (0.23) [−0.60, 0.29]	0.91 (0.57)+ [−0.19, 2.02]
Variance components (random effects)
Residual	124.89	124.89	124.89	124.89	124.89	124.89	124.89
Intercept	243.87	247.15	260.94	225.59	212.29	252.44	243.07
Time	37.59	38.69	39.68	34.81	32.23	39.58	35.53

MEMS Caps Medication Event Monitoring System Caps, Sx symptoms

95% Confidence Interval depicted in brackets beneath each estimated parameter

^***= p < 0.001;

^**= p < 0.01;

^*= p < 0.05;

⁺= p < 0.15