Table 1.
Description of the Study Groups Considered in the Meta-Analysis (Ordered by Geographical Regions)
|
Description of Group |
No. (%) of Individuals with I103 |
||||
| Study Group/Investigators | Obese | Nonobese | Obese | Nonobese | OR (95% CI) |
| Augsburg | German probands from the KORA study (BMI >90th percentile) | German probands from the KORA study (BMI ⩽50th percentile) | 9/383 (2.3%) | 78/1,951 (4.0%) | .58 (.29–1.16) |
| Essen | Obese German probands (BMI ⩾30 kg/m2) | Nonobese German probands (BMI <25kg/m2) | 16/489 (3.3%) | 8/172 (4.7%) | .69 (.29–1.65) |
| Hinney et al. 2003 | German children and adolescents (BMI ⩾90th percentile) | Normal-weight and underweight German students | 15/808 (1.9%) | 9/327 (2.8%) | .67 (.29–1.54) |
| Branson et al. 2003 | Severely obese Swiss probands (BMI >35 kg/m2) | Normal-weight Swiss probands (BMI ⩽25 kg/m2) | 11/469 (2.3%) | 1/25 (4.0%) | .58 (.07–4.65) |
| Vaisse et al. 2000 | Morbidly obese French probands (BMI >40 kg/m2) | Nonobese French probands from two studies | 8/209 (3.8%) | 11/366 (3.0%) | 1.28 (.51–3.25) |
| Dubern et al. 2001 | Severely obese French children (SDSBMI >3) | Never-obese normal-weight French adults | 1/63 (1.6%) | 8/283 (2.8%) | .55 (.07–6.49) |
| Gotoda et al. 1997 | British white males (BMI >28 kg/m2) | British white males (BMI <22 kg/m2) | 8/190 (4.2%) | 6/132 (4.5%) | .92 (.31–2.73) |
| Farooqi et al. 2000, 2003 | U.K. probands with early-onset obesity | Healthy nonobese U.K. whites | 10/500 (2.0%) | 1/54 (1.9%) | 1.08 (.14–8.62) |
| Jacobson et al. 2002a | Females from the SOS project (Sweden) (BMI ⩾30 kg/m2) | Females from the SOS project (Sweden) (BMI <30 kg/m2) | 5/144 (3.5%) | 6/140 (4.3%) | .80 (.24–2.69) |
| Rosmond et al. 2001b | Males from a Swedish 1944-birth cohort (BMI ⩾30 kg/m2) | Males from a Swedish 1944-birth cohort (BMI <30 kg/m2) | 0/38 (.0%) | 13/230 (5.7%) | …c |
| Marti et al. 2003 | Obese Spanish probands (BMI >30 kg/m2) | Normal-weight Spanish probands (BMI <25 kg/m2) | 1/159 (.6%) | 0/154 (.0%) | …c |
| Gu et al. 1999 | European Americans (BMI ⩾ 30 kg/m2) | European Americans (BMI <30 kg/m2) | 1/82 (1.2%) | 2/50 (4.0%) | .30 (.03–3.36) |
| Jacobson et al. 2002 | Black females from two studies (United States) (BMI ⩾ 30 kg/m2) | Black females from the HERITAGE study (United States) (BMI <30 kg/m2) | 0/47 (0.0%) | 2/48 (4.2%) | …c |
| Ohshiro et al. 1999 | Extremely obese Japanese probands (past max-BMI ⩾35 kg/m2) | Healthy nonobese Japanese probands (past max-BMI ⩽20 kg/m2) | 1/50 (2.0%) | 4/150 (2.7%) | .74 (.08–6.82) |
| Meta-analysis | Obese individuals from all studies (N=3,631) | Nonobese individuals from all studies (N=4,082) | 2.1%d | 3.5%d | .69 (.50–.96) |
a
Carrier frequencies of the unrelated individuals, received by personal communication.
b
Carrier frequencies, according to different BMI categories, received by personal communication.
c
For study groups with 0 carriers in one group, no OR could be calculated.
d
Mean of the single-study percentages.