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. 2025 Mar 11;26(6):2501. doi: 10.3390/ijms26062501
7TM receptors seven transmembrane domain receptors, also known as G protein-coupled receptors (GPCRs)
9-PAHSA palmitic-acid-9-hydroxy-stearic-acid
Ω-3 FAs omega-3-fatty acids
AD Alzheimer’s disease
ALA alpha-linolenic acid
ANGPTL2 angiopoietin-like 2 protein
APCs antigen-presenting cells
ARRβ2 beta-arrestin 2
AT adipose tissue
ATP adenosine triphosphate
BAT brown adipose tissue
BMI body mass index
cAMP cyclic adenosine 3,5-monophosphate
CCK cholecystokinin
CICR calcium-induced calcium release
CNS central nervous system
cpdA compound A
CRF2 corticotropin-releasing factor type-2
CRF2R corticotropin-releasing factor type-2 receptor
CTL cytotoxic T lymphocyte
DAG diacyl glycerol
DHA docosahexaenoic acid
DIO diet-induced obesity
DPP-IV dipeptidyl peptidase-IV
EC50 half maximal effective concentration
ECL1–ECL3 three extracellular loops (from 1 to 3) forming the GPCR
eNAMPT extracellular nicotinamide phosphoribosyl transferase
EPA eicosapentaenoic acid
ERK1/2 extracellular regulated protein kinases 1/2
ERKs extracellular signal-regulated kinases
FDA U.S. Food and Drug Administration
FFAR1 free fatty acid receptor 1, also known as GPR40
FFAR4 free fatty acid receptor 4, also known as GPR120
FFAs free fatty acids
FGF-21 fibroblast growth factor-21
GDP guanosine diphosphate
GEF guanine nucleotide exchange factor
GHIH growth hormone-inhibiting hormone, also known as somatotropin release inhibiting factor (SRIF)
GIP gastric inhibitory polypeptide, also known as glucose-dependent insulinotropic polypeptide
GLP-1 glucagon-like peptide-1
GLUT4 glucose transporter type 4
GPCRs G protein-coupled receptors, also known as seven transmembrane domain (7TM) receptors
GPR40 G protein-coupled receptor 40, also known as FFAR1
GPR120 G protein-coupled receptor 120, also known as FFAR4
GPR120L a long form of GPR120,
GPR120S a short form of GPR120
GRAFS acronym defining classification of GPCRs that stands for glutamate, rhodopsin, adhesion, Frizzled/Taste2, and Secretin
GSIS glucose-stimulated insulin secretion
GSSS glucose-stimulated somatostatin secretion
GTP guanosine triphosphate
HbA1c hemoglobin A1C
HDL high-density lipoprotein
HEC human embryonic kidney
HFD high-fat diet
HIF-1 hypoxia-induced factor 1
ICL1–ICL3 three intracellular loops (from 1 to 3) forming the GPCR
IFN-γ interferon gamma
IKKβ nuclear factor kappa-B kinase
IL1R interleukin 1 receptor
IL-1RA interleukin 1 receptor antagonist
ILs interleukins, including IL-1β, IL-6, IL-8),
iNAMPT intracellular nicotinamide phosphoribosyl transferase
INSR insulin receptor
IP3 inositol 1,4,5-trisphosphate
IR insulin resistance
IRSs insulin receptor substrates
IVGTT intravenous glucose tolerance test
JNK c-Jun N-terminal kinase
KATP ATP-sensitive potassium channels
LA linolenic acid
LCFAs long-chain fatty acids
LPS lipopolysaccharide
MAP3K7 TGF-β activated kinase 1
M1, M2 macrophages classically activated and alternatively activated macrophages, respectively
MARTs mono ADP-ribosyl transferases
MCFAs medium-chain fatty acids
MCP-1 monocyte chemoattractant protein-1, also known as CCL2
MMPs matrix metalloproteinases
MiMP mitochondrial membrane potential
NAc nucleus accumben
N.A.D. denotes no data or ambiguous data
NAFLD nonalcoholic fatty liver disease
NAMPT nicotinamide phosphoribosyl transferase
NCG N-Carbamoyl-Beta-D-Glucopyranosylamine
NEMO nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) essential modulator
NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells
NLRP3 inflammasome nucleotide-binding oligomerization domain (NOD), leucine-rich repeat (LRR)-containing protein (NLR) family member 3 inflammasome
PARPs poly ADP-ribose polymerases
PC1/3 proprotein convertase 1/3
PDX1 pancreatic duodenal homeobox-1
pERK1/2 phosphorylated extracellular regulated protein kinases 1/2
PI3K phosphoinositide 3-kinase
PIP2 phosphatidylinositol 4,5-bisphosphate
PKC protein kinase C
PLC-β phospholipase C-beta
PPARγ peroxisome proliferator-activated receptor gamma
PUFAs polyunsaturated fatty acids
RAW 264.7 monocyte/macrophage-like cell line
ROS reactive oxygen species
RXRα retinoid X receptor alpha
SAAs sulfur amino acids
S1P sphingosine-1-phosphate
S1P1 sphingosine-1-phosphate receptor-1
SCFAs short-chain fatty acids
SNP single-nucleotide polymorphism
SPM specialized pro-resolving mediator
SRIF somatotropin release inhibiting factor, also known as growth hormone-inhibiting hormone (GHIH)
STC-1 secretin tumor cell line 1
S-V cells stromal–vascular cells
T2D type 2 diabetes mellitus
TAB1 TAK1 binding protein 1
TAK1 TGFβ-activated kinase 1
TGFβ transforming growth factor-beta
Th1, Th2, Th17 types of lymphocyte subpopulations
TLR4 Toll-like receptor 4
TM1–TM7 seven transmembrane heptahelical structures (from 1 to 7) forming GPCR
TNFR tumor necrosis factor receptor
UCN3 urocortin 3
UCP1 uncoupling protein 1
VEGF vascular endothelial growth factor
WAT white adipose tissue
ZDF Zucker Diabetic Fatty (rats)