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Determination of the cutoff value for mRNA variables in identifying the patient group.
| Cutoff Value | AUC (95% CI) | p | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | DeLong Test | |
|---|---|---|---|---|---|---|---|---|
| SIRT-1 | ≥22.96 | 0.990 a (0.977–1) | <0.001 | 91.11% | 100% | 100% | 89.74% | |
| SIRT-3 | ≥25.3 | 0.740 b (0.625–0.855) | <0.001 | 80% | 77.14% | 81.82% | 75% | |
| SIRT-6 | ≥27.72 | 0.997 a (0.991–1) | <0.001 | 100% | 94.29% | 95.74% | 100% |
a,b: There is no difference between AUC values with the same letter. SIRT-1: Sirtuin 1. SIRT-3: Sirtuin 3. SIRT-6: Sirtuin 6.
