5′-DFUR	5′-deoxy-5-fluorouridine
5-FU	5-fluorouracil
AADC	L-amino acid decarboxylase
AAMD	All-atom MD
ABC	ATP-Binding Cassette
ACh	Acetylcholine
AChE	Acetylcholinesterase
ACV	Acyclovir
ADEPT	Antibody-directed enzyme prodrug therapy
ADME	Absorption, distribution, metabolism, and excretion
ALK	Anaplastic lymphoma kinase
ANNs	Artificial neural networks
API	Adenosine triphosphate
AT1	Active pharmaceutical ingredients
ATP	Angiotensin II type-1
AUC	Area under the curve
BBB	Blood–brain barrier
BCS	Biopharmaceutical Classification System
BNP	Brain natriuretic peptide
BRD4	Bromodomain-containing protein 4
CDSs	Chemical delivery systems
CES1	Carboxylesterase 1
CGMD	Coarse-grained MD
CME	Cystoid macular edema
CNS	Central nervous system
COX-1	Cyclooxygenase-1
COX-2	Cyclooxygenase-2
CPPs	Cell-penetrating peptides
CRBN	Cereblon
DAR	Drug-to-antibody ratio
DBCO	Dibenzocyclooctyne
DC50	Degradation Concentration 50%
deuHTBZ	Deuterated dihydrotetrabenazine isomers
DL	Deep learning
DMF	Dimethyl fumarate
dThdPase	Cytidine deaminase and thymidine phosphorylase
E. coli	Escherichia coli
EC50	Effective concentration
EML4-ALK	Echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase
ESBLs	Extended-spectrum β-lactamases
FDA	Food and Drug Administration
FOLR1	Folate receptor-1
FRs	Folate receptors
GI50	Growth Inhibition 50%
Gly	Glycine
GSH	Glutathione
HCAR2	Hydroxycarboxylic acid receptor 2
HCV	Chronic hepatitis C virus
His	Histidine
HIV	Human immunodeficiency virus
hPEPT-1	Human peptide transporter 1
IC50	Inhibitory concentration
IMPDH	Inosine monophosphate dehydrogenase
LASSO	Least Absolute Shrinkage and Selection Operator
LAT1	l-type amino acid transporter
LC-MS	Liquid Chromatography–Mass Spectrometry
LDV	Ledipasvir
Leu	Leucine
LogD	Logarithm of the distribution coefficient
LogP	Logarithm of the octanol/water partition coefficient
MBLs	Metallo-β-lactamases
MD	Molecular dynamics
MDCK	Madin–Darby Canine Kidney
ML	Machine learning
MOFs	Metal–organic frameworks
NDDSs	Nanosized Drug Delivery Systems
NF-κB	Factor nuclear kappa B
Nrf2	Erythroid-derived factor 2
NSAID	Non-steroidal anti-inflammatory drugs
NSCLC	Non-small cell lung cancer
OATP	Organic Anion Transporting Polypeptide
PAMPA	Parallel Artificial Membrane Permeability Assay
Papp	Apparent permeability coefficient
PBPs	Penicillin-binding proteins
PCFT	Proton-coupled folate transporter
PD-1	Cell death protein 1
Pe	Permeability coefficient
Peff	Effective permeation
PEG	Polyethylene glycol
PGE2	Prostaglandin E2
POI	Protein of interest
POM	Pivaloyloxymethyl
PROTACs	PROteolysis TArgeting Chimeras
PS-1	Presenilin-1
RAFT	Reversible Addition Fragmentation chain Transfer
RFC	Reduced folate carrier
RIPK2	Serine- and threonine-protein kinase 2
Ro5	Rule of five
SLC	Solute-Linked Carrier
SLCO	Solute Carrier Organic Anion
SOF	Sofosbuvir
STAT3	Signal transducer and activator of transcription 3
TAF	Tenofovir alafenamide
TEER	Transepithelial electrical resistance
TFV	Tenofovir
TFV-DP	Tenofovir diphosphate
Tyr	Tyrosine
Val	Valine
VHL	von Hippel–Lindau protein
VMAT2	Vesicular monoamine transporter 2
WHO	World Health Organization