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. 2025 Feb 14;134(4):917–1008. doi: 10.1016/j.bja.2025.01.015

Recommendation Table 29.

Recommendations for kidney protection

Recommendations Class a Level b Ref c
Routinely targeting a high MAP using vasoconstrictors is not recommended during CPB to reduce AKI. III A 377,378,380,381
The intravenous infusion of a balanced mixture of amino acids should be considered perioperatively, including during CPB, to reduce the occurrence of AKI. IIa B 383
The perioperative use of intravenous NAC may be considered in patients with CKD to reduce AKI after cardiac surgery. IIb B 385, 386, 387

AKI: acute kidney injury; CKD: chronic kidney injury; CPB: cardiopulmonary bypass; MAP: mean arterial pressure; NAC: N-acetylcysteine.

a

Class of recommendation.

b

Level of evidence.

c

References.