Table 3.
Association of macrocirculatory hemodynamic and tissue perfusion variables with endpoints in univariable Cox model
| Nevents/N (%) | Univariable cox model | Prognostic value | |||
|---|---|---|---|---|---|
| HR (CI 95%) | p value | C-index (CI 95%) | p value | ||
| Outcome = death at 30 days | |||||
| Mean SAP (per 10 mmHg decrease) | 44/118 (37%) | 1.41 (1.14–1.74) | 0.001 | 0.635 (0.552–0.718) | 0.001 |
| Mean SAP < 95 mmHg | 44/118 (37%) | 2.09 (1.10–3.94) | 0.024 | 0.580 (0.510–0.650) | 0.025 |
| Mean MAP (per 10 mmHg decrease) | 44/118 (37%) | 1.74 (1.25–2.41) | 0.0010 | 0.644 (0.560–0.728) | 0.0008 |
| Mean MAP < 70 mmHg | 44/118 (37%) | 1.89 (1.04–3.43) | 0.037 | 0.584 (0.510–0.657) | 0.027 |
| Mean ScvO2 (per 1% decrease) | 43/115 (37%) | 1.03 (1.00–1.06) | 0.023 | 0.600 (0.506–0.693) | 0.036 |
| Mean ScvO2 < 70% | 43/115 (37%) | 1.80 (0.99–3.28) | 0.054 | 0.586 (0.511–0.661) | 0.025 |
| Mean CO (per 1 L/min decrease) | 43/114 (38%) | 1.62 (1.24–2.13) | 0.0004 | 0.668 (0.581–0.756) | 0.0002 |
| Mean CO < 3.5 L/min | 43/114 (38%) | 2.38 (1.30–4.33) | 0.005 | 0.617 (0.544–0.691) | 0.002 |
| Mean CI (per 1 L/min/m2 decrease) | 44/117 (38%) | 2.04 (1.24–3.34) | 0.005 | 0.626 (0.538–0.715) | 0.005 |
| Mean CI ≤ 1.8 L/min/m2 | 44/117 (38%) | 1.81 (0.96–3.41) | 0.068 | 0.577 (0.503–0.651) | 0.042 |
| Mean CPI (per 0.1 W/m2 decrease) | 44/117 (38%) | 1.57 (1.19–2.08) | 0.001 | 0.648 (0.563–0.732) | 0.0006 |
| Mean CPI < 0.27 W/m2 | 44/117 (38%) | 2.37 (1.22–4.61) | 0.011 | 0.584 (0.516–0.653) | 0.016 |
| Mean ∆PCO2 (per 1 mmHg increase) | 43/114 (38%) | 1.14 (1.07–1.22) | 0.0001 | 0.623 (0.529–0.717) | 0.010 |
| Mean ∆PCO2 ≥ 9 mmHg | 43/114 (38%) | 2.75 (1.51–5.02) | 0.0010 | 0.629 (0.556–0.702) | 0.0005 |
| Mean ∆PCO2/C(a-v)O2 (per 1 mmHg/mL increase) | 42/113 (37%) | 1.10 (1.02–1.18) | 0.012 | 0.610 (0.527–0.694) | 0.009 |
| Mean ∆PCO2/C(a-v)O2 ≥ 1.5 mmHg/mL | 42/113 (37%) | 2.15 (1.08–4.29) | 0.029 | 0.598 (0.532–0.665) | 0.004 |
| Mean arterial lactate (per 1 mmol/L increase) | 42/116 (36%) | 1.29 (1.20–1.38) | < 0.0001 | 0.764 (0.685–0.842) | < 0.0001 |
| Mean arterial lactate ≥ 3 mmol/L | 42/116 (36%) | 4.18 (2.13–8.19) | < 0.0001 | 0.687 (0.623–0.751) | < 0.0001 |
SAP: systolic arterial pressure; MAP: mean arterial pressure; CO: cardiac output; CI: cardiac index; CPI: cardiac power index; ScvO2: central venous oxygen saturation; P(v-a)CO2/C(a-v)O2 ratio: ratio of venous-arterial carbon dioxide tension difference to arterial-venous oxygen content difference (or ∆PCO2/C(a-v)O2)
CI: confidence interval, HR: hazard ratio