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. 2005 Aug 19;102(35):12489–12494. doi: 10.1073/pnas.0504325102

Fig. 3.

Fig. 3.

Sequence analysis of the IL-1β gene in inbred mouse strains. (a) Sequencing of the Il1b gene in three inbred strains. The intron-exon structure of the gene is schematized, with its position on mouse Chr2; double-pointed arrows indicating the PCR amplicons sequenced after amplification from tail DNA of Balb/cJ, SJL/J, and C57BL/6J mice. The bases at variable positions for each of the three strains are shown. (b) Additional sequencing in a broader panel of strains. Three of the Il1b amplicons shown in a were sequenced in DNA from a broader panel of inbred strains. White boxes, SJL haplotype; shaded, BALB/c haplotype; dotted, “private” variability of the non-domesticus strain CAST/EiJ; B6(P), reference sequence from public databases. (c) Genotyping for the -230 SNP of the IL-1b promoter, in the full panel of strains from the Mouse Phenome Project (plus DBA/1J and MRL/MpJ). The strains are separated into conventional and wild-derived inbreds.