Table 1. MET induces a time-dependent down-regulation of reelin mRNA and protein expression in the frontal cortex of mice.

	VEH	Methionine 5.2 mmol/kg twice a day
MET-drug targets	15-day	3-day	6-day	15-day
Reelin mRNA, attomole/μg RNA	170 ± 16	135 ± 33	117 ± 7*	97 ± 7**
Reelin/β-actin, OD ratio	0.54 ± 0.02	0.42 ± 0.012	0.29 ± 0.04*	0.22 ± 0.03**

Each value is the mean ± SE of five mice. ^*, P < 0.05 vehicle vs. MET; ^**, P < 0.01 vehicle vs. MET.